国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (8): 676-678.doi: 10.3760/cma.j.issn.1673422X.2017.09.008

• 综述 • 上一篇    下一篇

LINE-1在肿瘤研究中的新进展

唐美玲,吴建新,常会波   

  1. 100020 北京，首都儿科研究所生物化学室
  • 出版日期:2017-09-08 发布日期:2017-10-31
  • 通讯作者: 常会波，Email： huibochang2012@163.com E-mail:huibochang2012@163.com
  • 基金资助:

    国家自然科学基金（81301773）； 首都儿科研究所方向性引导基金（FX-2016-03）

Research advances of LINE-1 in tumor

Tang Meiling, Wu Jianxin, Chang Huibo   

  1. Department of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, China
  • Online:2017-09-08 Published:2017-10-31
  • Contact: Chang Huibo E-mail:huibochang2012@163.com
  • Supported by:

    National Natural Science Foundation of China (81301773); Capital Institute of Pediatrics Directional Guidance Fund (FX-2016-3)

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摘要： 长散布核元件-1（LINE-1）序列的异常与肿瘤的发生发展有着密切关系。LINE1过表达可以促进细胞增殖，对肿瘤的预后及转移产生影响。LINE1反转录转座和甲基化状态在临床诊断、预后、疾病监测以及治疗等方面有着潜在的应用价值。

关键词: 肿瘤, 甲基化, 反转录因子, 长散布核元件-1

Abstract: The abnormality of long interspersed nuclear element1 (LINE1) is closely related to the occurrence and development of tumor. Overexpression of LINE1 can promote cell proliferation and affect the prognosis and metastasis of tumor. The retrotransposition and methylation status of LINE1 have potential application value in clinical diagnosis, prognosis, disease monitoring and treatment.

Key words: Neoplasms, Methylation, Retroelements, Long interspersed nuclear element-1