国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (8): 679-681.doi: 10.3760/cma.j.issn.1673422X.2017.09.009

• 综述 • 上一篇    下一篇

肠道微生物失调促进肿瘤发生

张百红, 岳红云   

  1. 730050 兰州军区兰州总医院肿瘤科（张百红），眼科（岳红云）
  • 出版日期:2017-09-08 发布日期:2017-10-31
  • 通讯作者: 张百红，Email: bhzhang1999@126.com E-mail:bhzhang1999@126.com

Dysbiosis of gut microbiota drives cancer development

Zhang Baihong, Yue Hongyun   

  1. Department of Oncology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou 730050, China
  • Online:2017-09-08 Published:2017-10-31
  • Contact: Zhang Baihong E-mail:bhzhang1999@126.com
  • Supported by:

    Natural Science Foundation of Gansu Province of China (1308RJZA181)

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摘要： 多项研究证实肠道微生物群作为环境因素在肿瘤的发生中发挥重要作用。肠道微生物促进肿瘤发生的机制包括影响免疫功能、刺激炎症反应、诱导DNA损伤、产生促癌代谢物和激活肿瘤信号。肿瘤的微生物治疗前景广阔。

关键词: 肿瘤, 微生物组, 肠道微生物, 肿瘤发生

Abstract: Numerous studies support the importance of gut microbiota as environment factors in the development of cancer. The mechanisms that gut microbiota drive certain cancers include impacting immunity, modulating inflammation, inducing DNA damage, producing cancer promoting metabolites and regulating signaling pathway. Microbiomebased therapies provide potential prospects for cancer treatment.

Key words: Neoplasms, Microbiome, Gut microbiota, Tumorigenesis