国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (2): 145-147.doi: 10.3760/cma.j.issn.1673422X.2017.02.018

• 综述 • 上一篇    下一篇

微小RNA let-7与食管癌

孙国庆,杨锡贵,姜超   

  1. 250117 济南，山东省肿瘤医院肿瘤内科 济南大学 山东省医学科学院医学与生命科学学院（孙国庆）；山东省医学科学院附属医院内三科（杨锡贵、姜超）
  • 出版日期:2017-02-08 发布日期:2017-01-04
  • 通讯作者: 杨锡贵，Email: zlysxgy@126.com E-mail:zlysxgy@126.com

MicroRNA let-7 and esophagus cancer

Sun Guoqing, Yang Xigui, Jiang Chao   

  1. Department of Internal Medicine Oncology, Shandong Cancer Hospital； School of Medicine and Life Science, University of Ji′nan and Shandong Academy of Medical Sciences, Ji′nan 250117, China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Yang Xigui E-mail:zlysxgy@126.com

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摘要： 微小RNA（miRNA）的发现为食管癌的诊断和治疗开辟了新的思路。let7是目前研究最为广泛的miRNA之一，在多种肿瘤中表达下调。let7能够靶向高迁移率蛋白A2（HMGA2）从而抑制细胞增殖，发挥抑癌基因的作用。研究发现分化程度越低的细胞，let7表达水平越低，其有望作为低分化肿瘤的标志。此外，let7与食管癌放化疗敏感性也密切相关。

关键词: 食管肿瘤, 治疗, 作用机制, let-7

Abstract: The discovery of microRNA (miRNA) has opened up a new train of thought for the diagnosis and treatment of esophagus cancer. let-7 is one of the most widely research of miRNA. In a variety of tumors, the expression of let-7 is downregulated. let-7 can play the role of tumor suppressor gene by targeting to high mobility group A2 (HMGA2) and inhibit the cell proliferation. Recent studies have shown that the lower the degree of differentiation of cells, let-7 expression level is lower. It is expected as a symbol of poorly differentiated tumors. In addition, let-7 and esophagus cancer′s radiation and chemotherapy sensitivity are closely related.

Key words: Esophagus neoplasms, Therapy, Mechanism, let-7