国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (2): 142-144.doi: 10.3760/cma.j.issn.1673422X.2017.02.017

• 综述 • 上一篇    下一篇

UCA1在消化道肿瘤中的表达及作用机制

赵义,燕善军,王启之   

  1. 233000 蚌埠医学院第一附属医院消化内科
  • 出版日期:2017-02-08 发布日期:2017-01-04
  • 通讯作者: 王启之，Email: wangqz2004@sina.com E-mail:wangqz2004@sina.com

Expression and mechanism of UCA1 in gastrointestinal tumors

Zhao Yi, Yan Shanjun, Wang Qizhi   

  1. Department of Gastroenterology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Wang Qizhi E-mail:wangqz2004@sina.com

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摘要： 尿路上皮癌相关1基因（UCA1）是一种长非编码RNA，无编码蛋白质的功能。UCA1在多种肿瘤中呈高表达，在肿瘤的发生发展中发挥重要作用。研究表明UCA1在胃癌、结直肠癌和肝癌等消化道肿瘤中发挥致癌基因作用，参与调控细胞的增殖、转移和化疗耐药性。

关键词: 消化道肿瘤, 长非编码RNA, 尿路上皮癌相关1

Abstract: Urothelial carcinoma associated 1 (UCA1) is a kind of long noncoding RNA (lncRNA), which has no capacities for coding proteins. UCA1 overexpresses in diverse tumors, and plays a pivotal role in initiation and progression of tumors. Researches indicate that UCA1 may function as an oncogene in gastrointestinal tumors, such as gastric cancer, colorectal cancer and hepatocellular cancer, and participate in regulating cell proliferation, metastasis and chemo-resistance.

Key words: Gastrointestinal neoplasms, Long non-coding RNA, Urothelial carcinoma associated 1