竞争性内源RNA在原发性肝癌中的研究进展

doi:10.3760/cma.j.issn.1673422X.2017.03.019

摘要/Abstract

摘要： 竞争性内源RNA(ceRNA)转录本可通过与微小RNA（miRNA）竞争性结合相同的 miRNA应答元件(MRE)，从而解除或减轻miRNA对靶基因的抑制作用。近期研究表明，许多基因可作为ceRNA，通过竞争性结合相同的致瘤性或抑瘤性基因，在肝癌发生发展中起促进或抑制肿瘤生成的作用。

关键词: 肝肿瘤, 微RNAs, 长非编码RNA

Abstract: Competing endogenous RNAs (ceRNAs) transcripts can communicate with microRNAs (miRNAs) through competitively binding the common miRNA response elements (MREs), which remove or decrease the repression of target genes of miRNAs. The present studies indicate that a large amount of genes, serving as ceRNAs, can promote or inhibit the occurrence of liver cancer by competing the binding site of same genes that can promote or suppress tumorigenesis．

Key words: Liver neoplasms, MicroRNAs, Long noncoding RNA

何晓琴,徐细明. 竞争性内源RNA在原发性肝癌中的研究进展[J]. 国际肿瘤学杂志, 2017, 44(3): 231-234.

He Xiaoqin, Xu Ximing. Research progress of the competing endogenous RNA in primary hepatocellular carcinoma[J]. Journal of International Oncology, 2017, 44(3): 231-234.

参考文献

［1］ Casane D, Fumey J, Laurenti P. ENCODE apophenia or a panglossian analysis of the human genome［J］. Med Sci (Paris), 2015, 31(6/7): 680-686. DOI: 10.1051/medsci/20153106023. ［2］ Veneziano D, Di Bella S, Nigita G, et al. Noncoding RNA: current deep sequencing data analysis approaches and challenges［J］. Hum Mutat, 2016, 37（12）： 1283-1298. DOI: 10.1002/humu.23066. ［3］ Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition［J］. Nature, 2014, 505(7483): 344-352. DOI: 10.1038/nature12986. ［4］ Zhang Y, Xu Y, Feng L, et al. Comprehensive characterization of lncRNAmRNA related ceRNA network across 12 major cancers［J］. Oncotarget, 2016, 7（39）： 64148-64167. DOI: 10.18632/oncotarget.11637. ［5］ Liu XH, Sun M, Nie FQ, et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR3313p in gastric cancer［J］. Mol Cancer, 2014, 13(1): 92. DOI: 10.1186/14764598 1392. ［6］ Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015［J ］. CA Cancer J Clin, 2016, 66(2): 115-132. DOI: 10.3322/caac.21338. ［7］ Yang C, Wu D, Gao L, et al. Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives［J］. Oncotarget, 2016, 7(12): 13479-13490. DOI: 10.18632/oncotarget.7266. ［8］ Cao C, Sun J, Zhang D, et al. The long intergenic noncoding RNA UFC1, a target of microRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of βcatenin in HCC cells［J］. Gastroenterology, 2015, 148(2): 415-426.e18. DOI: 10.1053/j.gastro.2014.10.012. ［9］ Yoo S, Kim HH, Kim P, et al. A HuDZBP1 ribonucleoprotein complex localizes GAP43 mRNA into axons through its 3′ untranslated region AUrich regulatory element［J］. J Neurochem, 2013, 126(6): 792-804. DOI: 10.1111/jnc.12266. ［10］ An Y, Furber KL, Ji S. Pseudogenes regulate parental gene expression via ceRNA network［J］. J Cell Mol Med, 2017, 21（1）： 185-192. DOI: 10.1111/jcmm.12952. ［11］ Thomson DW, Dinger ME. Endogenous microRNA sponges: evidence and controversy［J］. Nat Rev Genet, 2016, 17(5): 272-283. DOI: 10.1038/nrg.2016.20. ［12］ Kluiver J, SlezakProchazka I, SmigielskaCzepiel K, et al. Generation of miRNA sponge constructs［J］. Methods, 2012, 58(2): 113-117. DOI: 10.1016/j.ymeth.2012.07.019. ［13］ Tay FC, Lim JK, Zhu H, et al. Using artificial microRNA sponges to achieve microRNA lossoffunction in cancer cells［J］. Adv Drug Deliv Rev, 2015, 81(81): 117-127. DOI: 10.1016/j.addr.2014.05.010. ［14］ Giza DE, Vasilescu C, Calin GA. MicroRNAs and ceRNAs: therapeutic implications of RNA networks［J］. Expert Opin Biol Ther, 2014, 14(9): 1285 -1293. DOI: 10.1517/14712598.2014.920812. ［15］ Karreth FA, Pandolfi PP. ceRNA crosstalk in cancer: when cebling rivalries go awry［J］. Cancer Discov, 2013, 3(10): 1113-1121. DOI: 10.1158/21598290.CD130202. ［16］ Dong P, Xiong Y, Watari H, et al. MiR137 and miR34a directly target Snail and inhibit EMT, invasion and sphereforming ability of ovarian cancer cells［J］. J Exp Clin Cancer Res, 2016, 35(1): 132. DOI: 10.1186/s130460160415y. ［17］ Dang Y, Luo D, Rong M, et al. Underexpression of miR34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting cMET［J］. PLoS One, 2013, 8(4): e61054. DOI: 10.1371/journal.pone.0061054. ［18］ ArriagaCanon C, FonsecaGuzmán Y, ValdesQuezada C, et al. A long noncoding RNA promotes full activation of adult gene expression in the chicken αglobin domain［J］. Epigenetics, 2014, 9(1): 173-181. DOI: 10.4161/epi.27030. ［19］ Gutschner T, Diederichs S. The hallmarks of cancer: a long noncoding RNA point of view［J］. RNA Biol, 2012, 9(6): 703-719. DOI: 10.4161/rna.20481. ［20］ Kallen AN, Zhou XB, Xu J, et al. The imprinted H19 lncRNA antagonizes let7 microRNAs［J］. Mol Cell, 2013, 52(1): 101-112. DOI: 10.1016/j.molcel.2013.08.027. ［21］ Wang F, Yuan JH, Wang SB, et al. Oncofetal long noncoding RNA PVT1 promotes proliferation and stem celllike property of hepatocellular carcinoma cells by stabilizing NOP2［J］. Hepatology, 2014, 60(4): 1278-1290. DOI: 10.1002/hep.27239. ［22］ Li SP, Xu HX, Yu Y, et al. LncRNA HULC enhances epithelialmesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR200a3p/ZEB1 signaling pathway［J ］. Oncotarget, 2016, 7（27）： 42431-42446. DOI: 10.18632/oncotarget.9883. ［23］ Deng L, Yang SB, Xu FF, et al. Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let7 sponge［J］. J Exp Clin Cancer Res, 2015, 34: 18. DOI: 10.1186/s1304601501367. ［24］ Fang L, Du WW, Yang X, et al. Versican 3′untranslated region (3′ UTR) functions as a ceRNA in inducing the development of hepatocellular carcinoma by regulating miRNA activity［J］. FASEB J, 2013, 27(3): 907-919. DOI: 10.1096/fj.12220905. ［25］ Zhao L, Li F, Taylor EW. Can tobacco use promote HCVinduced miR122 hijacking and hepatocarcinogenesis?［J］. Med Hypotheses, 2013, 80(2): 131-133. DOI: 10.1016/j.mehy.2012.11.009. ［26］ Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency［J］. Nature, 2013, 495(7441): 333-338. DOI: 10.1038/nature11928. ［27］ Shang X, Li G, Liu H, et al. Comprehensive circular RNA profiling reveals that hsa_circ_0005075, a new circular RNA biomarker, is involved in hepatocellular crcinoma development［J］. Medicine (Baltimore), 2016, 95 (22): e3811. DOI: 10.1097/MD.0000000000003811. ［28］ Esposito F, De Martino M, Petti MG, et al. HMGA1 pseudogenes as candidate protooncogenic competitive endogenous RNAs［J］. Oncotarget, 2014, 5(18): 8341-8354. DOI: 10.18632/oncotarget.2202. ［29］ Cheng DL, Xiang YY, Ji LJ, et al. Competing endogenous RNA interplay in cancer: mechanism, methodology, and perspectives［J］. Tumour Biol, 2015, 36(2): 479-488. DOI: 10.1007/s132770153093z.

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