国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (1): 34-37.doi: 10.3760/cma.j.issn.1673422X.2017.01.009

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 肠道微生态与肿瘤免疫调节的相关研究

 肖俊娟, 毕振旺, 李岩   

  1. 250014 济南，山东省千佛山医院肿瘤化疗科（肖俊娟、李岩）；山东省疾病控制中心细菌所（毕振旺）
  • 出版日期:2017-01-08 发布日期:2016-12-07
  • 通讯作者: 李岩，Email: liyan16766@163.com E-mail:liyan16766@163.com

Research of microbiota and tumor immunomodulatory

Xiao Junjuan, Bi Zhenwang, Li Yan.   

  1. Department of Oncology Chemotherapy, Qianfoshan Hospital of Shandong Province, Ji′nan 250014, China
  • Online:2017-01-08 Published:2016-12-07
  • Contact: Li Yan, Email: liyan16766@163.com E-mail:liyan16766@163.com

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摘要： 肠道微生态在消化、吸收、代谢、免疫以及抑制病原菌定植中起重要作用。肠道菌群既能调节机体的先天性免疫，又能通过细菌本身和其代谢产物刺激机体的获得性免疫应答。肠道菌群的失调可能导致机体免疫机制的异常，进而参与肿瘤的发生发展，特别是结直肠癌。

关键词: 肿瘤, 免疫, 肠道微生态

Abstract: The ecological balance of intestinal microbiota plays an important role in digestion, absorption,  metabolism, immunity and protection against pathogens. Intestinal microbiota can not only regulate the innate immunity of the body, but also can stimulate the immune response by the bacteria itself and its metabolites. The imbalance intestinal microbiota may lead to abnormal immune mechanism, and then participate in the occurrence and development of the tumor, especially colorectal cancer.

Key words: Neoplasms, Immunity, Intestinal microbiota