国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (1): 38-40.doi: 10.3760/cma.j.issn.1673-422X.2017.01.010

• 综述 • 上一篇    下一篇

核酸适配子在胶质瘤中的研究进展

寇哲文,彭立,张兴梅   

  1. 510515 广州，南方医科大学基础医学院神经生物学教研室
  • 出版日期:2017-01-08 发布日期:2016-12-07
  • 通讯作者: 张兴梅，Email: zxmray@hotmail.com E-mail:zxmray@hotmail.com
  • 基金资助:

    国家自然科学基金（81272509、30973481）

Nucleic acid aptamer and its research progress in glioma

Kou Zhewen, Peng Li, Zhang Xingmei   

  1. Department of Neurobiology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China
  • Online:2017-01-08 Published:2016-12-07
  • Contact: Zhang Xingmei, Email: zxmray@hotmail.com E-mail:zxmray@hotmail.com
  • Supported by:

    National Natural Science Foundation of China (81272509, 30973481)

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摘要： 核酸适配子是由指数级富集配体系统进化技术（SELEX）从寡核苷酸文库中筛选合成所得的一类核酸分子，它可特异结合靶分子，具有识别或抑制靶分子生物学活性的作用。针对胶质瘤的适配子是以胶质瘤细胞或已知的生物标志分子为靶标筛选得到的，它们可与纳米粒子、药物或分子探针相结合，用于胶质瘤的显像、靶向治疗和药物转运。

关键词: 神经胶质瘤, 适体, 核苷

Abstract: Nucleic acid aptamer is an oligonucleotide generated by the systematic evolution of ligands by exponential enrichment (SELEX) process from oligonucleotide library. Nucleic acid aptamer can bind to various targets with high specificity and  can recognize or inhibit the biological activity of targeting molecular. Gliomaspecific aptamers are developed by either targeting the glioma cells or known biomarkers, which can be coupled with nanoparticles, drugs or molecular probes, and can be applied in the imaging, targeted therapy and drug delivery of glioma.

Key words: Glioma, Aptamers, nucleotide