长非编码RNA在神经胶质瘤研究中的新进展

doi:10.3760/cma.j.issn.1673-422X.2020.02.007

摘要/Abstract

摘要：

神经胶质瘤是最常见的原发性颅内肿瘤,其本质上是一种多基因异常疾病。长非编码RNA(lncRNA)是一类长度超过200个核苷酸的非编码基因,通过调控肿瘤相关基因的表达或相关信号通路在肿瘤的发生发展中发挥着重要作用。lncRNA在神经胶质瘤中异常表达有助于神经胶质瘤表型的多样性。深入研究异常表达的lncRNA在神经胶质瘤发病机制和病理分级中的潜在作用,有望为临床靶向治疗神经胶质瘤提供新的思路。

关键词: RNA,长链非编码, 神经胶质瘤

Abstract:

Glioma is the most common primary intracranial tumor which is essentially a polygenic abnormal disease. Long non-coding RNA (lncRNA) is a class of noncoding genes with a length of more than 200 nucleotides. LncRNA plays an important role in tumorigenesis and development by regulating the expression of tumor-related genes or related signaling pathways. The abnormally expressions of lncRNA in gliomas contribute to the diversity of glioma phenotypes. In-depth study of the potential role of abnormally expressed lncRNA in the pathogenesis and pathological grading of gliomas will provide new ideas for clinical targeted treatment of gliomas.

Key words: RNA, long noncoding, Glioma

南阳, 钟跃. 长非编码RNA在神经胶质瘤研究中的新进展[J]. 国际肿瘤学杂志, 2020, 47(2): 98-102.

Nan Yang, Zhong Yue. New research advances of long non-coding RNA in glioma[J]. Journal of International Oncology, 2020, 47(2): 98-102.

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