国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (8): 489-491.doi: 10.3760/cma.j.issn.1673-422X.2019.08.009

• 综述 • 上一篇    下一篇

紫草素抗胶质瘤效应及其作用机制

衣琳1    邱实2   

  1. 1吉林省吉林市吉化集团公司总医院老年病科  132021； 2吉林省吉林市吉化集团公司总医院放化疗科  132021
  • 收稿日期:2019-05-09 修回日期:2019-05-16 出版日期:2019-08-08 发布日期:2019-10-31
  • 通讯作者: 邱实 E-mail:qiushi555@163.com

Anti-tumor effect and mechanisms of shikonin on gliomas

Yi Lin1, Qiu Shi2   

  1. 1Department of Geriatric Medicine, General Hospital of Jilin Chemical Industry Group of Jilin City of Jilin Province, Jilin 132021, China; 2Department of Radiotherapy and Chemotherapy, General Hospital of Jilin Chemical Industry Group of Jilin City of Jilin Province, Jilin 132021, China
  • Received:2019-05-09 Revised:2019-05-16 Online:2019-08-08 Published:2019-10-31
  • Contact: Qiu Shi E-mail:qiushi555@163.com

PDF

506

摘要： 紫草素具有抗肿瘤活性，不仅可抑制胶质瘤细胞的增殖、迁移与浸润，还可通过诱导活性氧簇生成等促进胶质瘤发生程序性坏死。紫草素联合内质网应激抑制剂及调控微小RNA表达可进一步提高其对胶质瘤的杀伤效应，通过纳米颗粒修饰紫草素有助于增强其对胶质瘤的靶向性。紫草素联合靶向治疗药物或化疗药物有望克服胶质瘤细胞的耐药问题。

关键词: 神经胶质瘤, 紫草素, 活性氧, 抗肿瘤药, 程序性坏死

Abstract: Shikonin has anti-tumor activity, and it not only can inhibit the proliferation, migration and infiltration of glioma cells, but also induce necroptosis of glioma cells via promoting the production of reactive oxygen species. Shikonin combined with endoplasmic reticulum stress inhibitors or regulatory tactics of micro-RNA expression may further enhance its killing effect on gliomas. Shikonin armed by nanoparticles shows increased  targetability to gliomas. Shikonin combined with tumor-targeted therapeutic drugs or chemotherapeutic drugs is expected to overcome the drug resistance of glioma cells.

Key words: Gliomas, Shikonin, Reactive oxygen species, Antineoplastic agents, Necroptosis