国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (8): 711-714.doi: 10.3760/cma.j.issn.1673422X.2016.09.018

• 综述 • 上一篇    下一篇

沙利度胺治疗常见非血液系统肿瘤的研究进展

雷蕾, 王娴, 王晓稼   

  1. 310022杭州，浙江省肿瘤医院乳腺肿瘤内科（雷蕾、王晓稼）；浙江大学附属邵逸夫医院肿瘤内科（王娴）
  • 出版日期:2016-09-08 发布日期:2016-08-04
  • 通讯作者: 王晓稼，Email: wxiaojia0803@163.com E-mail:wxiaojia0803@163.com
  • 基金资助:

     国家自然科学基金（81572715）；浙江省医药卫生科技计划（2015KYB052、2013KYB034）；浙江省中医药科学研究基金（2013ZA020）

Research progress of thalidomide in usual nonhematologic malignancies

Lei Lei, Wang Xian, Wang Xiaojia   

  1. Department of Breast Tumor Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
  • Online:2016-09-08 Published:2016-08-04
  • Contact: Wang Xiaojia E-mail:wxiaojia0803@163.com
  • Supported by:

    National Natural Science Foundation of China (81572715); Medical and Health Science and Technology Project of Zhejiang Province (2015KYB052, 2013KYB034); Traditional Chinese Medicine Program of Zhejiang Province (2013ZA020)

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被引次数

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摘要： 沙利度胺具有抗肿瘤血管生成、改善免疫功能和晚期肿瘤患者恶液质等抗肿瘤作用，在治疗老年去势抵抗性前列腺癌、化疗耐药后的晚期结直肠癌、晚期肝细胞癌及转移性乳腺癌等方面显示出一定的疗效。随着沙利度胺抗肿瘤机制的研究不断深入，更多的临床研究开始关注沙利度胺对非血液系统肿瘤的作用，尤其是其在治疗高危结直肠癌、原发性肝细胞癌的术后辅助治疗、晚期三阴性乳腺癌和难治性妇科肿瘤的挽救治疗等方面获得了一定的研究成果。

关键词: 肿瘤, 治疗应用, 沙利度胺

Abstract: Thalidomide has antitumor effects such as antitumor angiogenesis, improvement of immune function and cachexia of patients with advanced tumors, which has been effectively used in elderly patients with castrationresistant prostate cancer, chemotherapy resistant advanced colorectal cancer, advanced hepatocellular carcinoma and metastatic breast cancer. As the indepth study of the antitumor mechanism of thalidomide, more and more clinical researches have focused on the function of thalidomide on nonhematological malignancies, especially it has obtained some achivements in the postoperative adjuvant therapy for highrisk colorectal cancer and primary hepatocellular carcinoma and the salvage therapy for metastatic triplenegative breast cancer and refractory gynecological tumor.

Key words: Neoplasms, Therapeutic uses, Thalidomide