国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (8): 691-694.doi: 10.3760/cma.j.issn.1673422X.2016.09.013

• 综述 • 上一篇    下一篇

肿瘤群体性迁移模型与机制

薛同春,叶胜龙   

  1. 200032 上海，复旦大学附属中山医院肝癌研究所
  • 出版日期:2016-09-08 发布日期:2016-08-04
  • 通讯作者: 叶胜龙，Email: slye@shmu.edu.cn E-mail:slye@shmu.edu.cn

Models and mechanisms of collective cell migration in cancer

Xue Tongchun, Ye Shenglong   

  1. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
  • Online:2016-09-08 Published:2016-08-04
  • Contact: Ye Shenglong E-mail:slye@shmu.edu.cn

PDF

1786

摘要： 群体性迁移是胚胎发育过程中重要的细胞运动模式。近年研究发现，群体性迁移是恶性肿瘤细胞侵袭、转移的主要运动模式之一。肿瘤细胞能以群体的方式向间质及血管侵袭，其特征与单个肿瘤细胞侵袭运动明显不同，而其发生机制与肿瘤细胞细胞间连接、肿瘤细胞与间质微环境的相互作用密切相关。随着群体性迁移观察模型的逐步完善，参与调控群体性迁移的物理引导及化学引导机制以及相关信号调控、表观调节等分子机制正逐步被揭示。

关键词: 肿瘤, 细胞运动, 细胞迁移, 模型

Abstract: Collective migration is the essential movement style in embryonic development. Recent studies have found that collective migration is one of the main movement styles in invasion and metastasis of tumor cells. Tumor cells can invade into the stroma and microvascular in group, and the collective migration shows the unique characters when compared to the single cell movement. The potential mechanisms are closely correlated to the cellcell connection and interaction between tumor cells and microenvironment. With the gradual improvement of the observation models, the mechanisms about the physical or chemical guidance, the related signaling pathways, and the epigenetic regulation in collective migration will be elucidated.

Key words: Neoplasms, Cell movement, Cell migration, Models