国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (4): 285-288.doi: 10.3760/cma.j.issn.1673422X.2016.04.012

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3-磷酸肌醇依赖性蛋白激酶1在肿瘤发生发展及治疗中的作用

刘田田, 毕经旺   

  1. 250031 济南军区总医院肿瘤科（刘田田、毕经旺）；辽宁医学院研究生部（刘田田）
  • 出版日期:2016-04-08 发布日期:2016-03-02
  • 通讯作者: 毕经旺，Email: jingwangbi@live.cn E-mail:jingwangbi@live.cn

3Phosphoinositidedependent protein kinase1 in tumor genesis, development and treatment

Liu Tiantian, Bi Jingwang   

  1. epartment of Oncology, General Hospital, Ji′nan Command of the People′s Liberation Army, Ji′nan 250031, China; Graduate Department, Liaoning Medical University, Jinzhou 121000, China
  • Online:2016-04-08 Published:2016-03-02
  • Contact: Bi Jingwang E-mail:jingwangbi@live.cn

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被引次数

2

摘要： 【摘要】3磷酸肌醇依赖性蛋白激酶1（PDK1）是磷脂酰肌醇3激酶蛋白激酶B（PI3KAkt）通路的一个关键调节分子。PDK1可通过激活Akt，参与PI3KAkt信号通路的活化，促进肿瘤的发生、发展及浸润转移。目前已经发现PDK1在头颈部肿瘤、多发性骨髓瘤、胰腺癌、食管癌、结肠癌等多种恶性肿瘤中高表达。抑制PDK1过表达可为恶性肿瘤的治疗找到新的突破点。目前已有多种PDK1抑制剂投入生产，发挥了抗肿瘤作用

关键词: 肿瘤, 信号传导, 3磷酸肌醇依赖性蛋白激酶1

Abstract: 3phosphoinositide dependent kinase1 (PDK1) has been shown to be a critical regulator of the PI3KAkt pathway. PDK1 can activate Akt and participates in the activation of PI3KAkt signaling pathway to promote tumor development, invasion and metastasis. At present, it has been found that PDK1 is highly expressed in head and neck cancer, multiple myeloma, pancreatic cancer, esophageal cancer, colon cancer and other malignant tumors. Thereby inhibiting PDK1 overexpression may provide a new breakthrough for the treatment of malignant tumor. At present, many kinds of PDK1 inhibitors have been put into production, which plays an important role in tumor therapy.

Key words: Neoplasms, Signal transduction, 3Phosphoinositide dependent kinase1