国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (4): 282-284.doi: 10.3760/cma.j.issn.1673422X.2016.04.011

• 综述 • 上一篇    下一篇

纤维蛋白原与肿瘤相关性及其机制

李颖, 李大伟, 于洋力, 焦伟, 阎磊, 刘海南, 徐忠华   

  1. 250012 山东大学齐鲁医院泌尿外科
  • 出版日期:2016-04-08 发布日期:2016-03-02
  • 通讯作者: 徐忠华，Email: xuzhonghua1963@163.com E-mail:xuzhonghua1963@163.com
  • 基金资助:

    国家自然科学基金（81502213、81372335）；山东省自然科学基金（ZR2015HM046）

Relationship between fibrinogen and tumor and the mechanism

Li Ying, Li Dawei, Yu Yangli, Jiao Wei, Yan Lei, Liu Hainan, Xu Zhonghua   

  1. Department of Urology, Qilu Hospital of Shandong Unviersity, Ji′nan 250012, China
  • Online:2016-04-08 Published:2016-03-02
  • Contact: Xu Zhonghua E-mail:xuzhonghua1963@163.com
  • Supported by:

    National Natural Science Foundation of China（81502213，81372335）； Natural Science Foundation of Shandong Province（ZR2015HM046）

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被引次数

3

摘要： 纤维蛋白原(Fib)是一种常见的凝血功能相关蛋白，除参与血凝外，还与肿瘤密切相关。研究发现多种恶性肿瘤术前血浆Fib可明显升高，并与肿瘤进展、转移及预后密切相关。尽管Fib与肿瘤的相互作用机制尚未完全明了，将Fib作为肿瘤标志物及肿瘤治疗新方向已成为肿瘤研究的新热点。

关键词: 纤维蛋白原, 肿瘤, 肿瘤转移, 预后

Abstract: Fibrinogen (Fib) is one of the most common coagulation proteins, plays an important role in the coagulation cascade, and has a closed relationship with tumor. Studies indicate that the level of Fib has elevated in many kinds of cancer, and Fib is also closely correlated with the progression, metastasis and prognosis of tumor. Though the mechanism of the interaction of Fib and tumor is still unclear, Fib as a tumor marker and new therapy for these malignancies has been a new hotspot.

Key words: Fibrinogen, Neoplasms, Tumor metastasis, Prognosis