国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (4): 278-281.doi: 10.3760/cma.j.issn.1673422X.2016.04.010

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高迁移率族蛋白N在肿瘤中的研究进展

刘蓓莉, 万毅新   

  1. 730030 兰州大学第二医院呼吸科
  • 出版日期:2016-04-08 发布日期:2016-03-02
  • 通讯作者: 万毅新，Email: wanyixin1964@gmail.com E-mail:wanyixin1964@gmail.com

Research progression about the HMGN protein in tumor

Liu Beili, Wan Yixin   

  1. Department of Respiration, Second Hospital of Lanzhou University, Lanzhou 730030, China
  • Online:2016-04-08 Published:2016-03-02
  • Contact: Wan Yixin E-mail:wanyixin1964@gmail.com

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1072

被引次数

1

摘要： 高迁移率族蛋白N（HMGN）是细胞内普遍存在的一类核蛋白，属于高迁移率族蛋白家族。它们能直接与DNA和核小体结合，诱导染色质纤维结构的改变，进而影响细胞内转录、细胞分化过程和细胞对受损DNA的修复能力。肿瘤的发生与累积突变导致的转录异常密切相关，转录异常促使肿瘤细胞得以逃脱细胞周期的严密调控。研究显示，HMGN可以通过参与细胞周期调节及影响肿瘤细胞的生物学行为等方式，在肿瘤发生发展中发挥重要作用。

关键词: HMGN蛋白质类, 肿瘤, 细胞周期, 警报素

Abstract: High mobility group N (HMGN), one member of the high mobility group superfamily, is expressed ubiquitously in living cells. HMGN can bind directly to nucleosomes and modulate the structure of the chromatin fiber, which affect the cellular transcription profile and cellular differentiation and the ability to repair damaged DNA. The occurence of tumor is closely related to the abnormal transcription caused by accumulation of mutations. Abnormal transcription can prompt the tumor cells to escape from the tight regulation of cell cycle progression. Studies show that HMGN plays an important role in cancer progression by involving in the regulation of tumor cell cycle and affecting the biological behavior of tumor cells.

Key words: HMGN proteins, Neoplasms, Cell cycle, Alarmins