国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (3): 220-222.doi: 10.3760/cma.j.issn.1673-422X.2016.03.016

• 综述 • 上一篇    下一篇

胃癌相关长非编码RNA研究进展

丁志丽,袁爱华,陈维,施雪松,曹红勇   

  1. 210006 南京医科大学附属南京医院（南京市第一医院）普外科
  • 出版日期:2016-03-08 发布日期:2016-02-03
  • 通讯作者: 曹红勇,Email: njmuyah@163.com E-mail:njmuyah@163.com
  • 基金资助:

    南京市医学科技发展项目（ZKX14035）

Advances in the study of gastric cancer related long noncoding RNA

Ding Zhili, Yuan Aihua, Chen Wei, Shi Xuesong, Cao Hongyong   

  1. Department of General Surgery, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China
  • Online:2016-03-08 Published:2016-02-03
  • Contact: Cao Hongyong, Email: njmuyah@163.com E-mail:njmuyah@163.com
  • Supported by:

    Medical Science and Technology Development Project of Nanjing（ZKX14035）

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摘要： 长非编码RNA（lncRNA）在胃癌的发生和发展中发挥重要作用。最新研究表明，上调的H19、HOTAIR、TINCR、LINC00152及下调的MEG3、GAS5、LET、AA174084等lncRNA的异常表达与胃癌的发生、发展、侵袭转移及预后等密切相关。深入研究lncRNA与胃癌之间的关系，有望为胃癌的诊治提供新的契机。

关键词: 胃肿瘤, 肿瘤标记, 生物学, 诊断, 治疗

Abstract: Long noncoding RNAs (lncRNAs) have great impact on the carcinogenesis and progression of gastric cancer (GC). Recent studies show that the overexpression of H19, HOTAIR, TINCR and LINC00152 and the down-expression of MEG3, GAS5, LET and AA174084 are closely related to the occurrence, invasion, metastasis and prognosis of GC. lncRNAs provide an opportunity to develop new strategies for the diagnosis and treatment of GC.

Key words: Stomach neoplasms, Tumor markers, biological, Diagnosis, Therapy