国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (3): 223-225.doi: 10.3760/cma.j.issn.1673-422X.2016.03.017

• 综述 • 上一篇    下一篇

胰腺癌患者的免疫状态

 刘凤华,唐勇   

  1. 300060，天津医科大学肿瘤医院妇科肿瘤科（刘凤华），胰腺肿瘤科（唐勇）；国家肿瘤临床医学研究中心 天津市肿瘤防治重点实验室（刘凤华、唐勇）
  • 出版日期:2016-03-08 发布日期:2016-02-03
  • 通讯作者: 唐勇，Email: tli001@163.com E-mail:tli001@163.com
  • 基金资助:

    国家自然科学基金(81341068)

The immune status of pancreatic cancer patients

Liu Fenghua, Tang Yong   

  1. Department of Gynecological Cancer; State Clinical Oncology Medicine Research Center; Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Online:2016-03-08 Published:2016-02-03
  • Contact: Tang Yong, Email: tli001@163.com E-mail:tli001@163.com
  • Supported by:

    National Natural Science Foundation of China(81341068)

PDF

1557

被引次数

2

摘要： 在胰腺癌的发生发展中，患者的全身和肿瘤局部免疫状态均发生了改变，致使肿瘤逃脱机体免疫。这种机制包括全身和肿瘤局部抑制免疫细胞的诱导和相关细胞因子的产生。全身免疫状态的改变包括免疫抑制细胞的出现，T细胞亚群免疫功能的改变，自然杀伤细胞、淋巴因子激活的杀伤细胞功能的抑制等；肿瘤局部免疫状态表现出肿瘤浸润淋巴细胞功能的缺失、Th1/Th2细胞因子失衡等。

关键词: 胰腺肿瘤, 免疫

Abstract: During the development of pancreatic cancer, the local and whole immune state of the patients is constantly changing, and through which the cancer cells escape from the immune attack. The main immunologic mechanism includes the induction of tumor immune suppression cells and producing the related cytokines. The changes of the whole immune status include the increase of immunosuppressive cells, the change of the immune function of T cell subsets and the inhibition of natural killers and lymphokine activated killer cells. In the local tumor, the infiltrating lymphocytes loss the function, and the ratio of Th1/Th2 cytokines is imbalance.

Key words: Pancreatic neoplasms, Immunity