国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 622-624.doi: 10.3760/cma.j.issn.1673422X.2015.08.017

• 综述 • 上一篇    下一篇

成纤维细胞生长因子受体3在乳腺癌中的研究进展

吴昊,姜永冬,庞达   

  1. 150081 哈尔滨医科大学附属第三医院乳腺外科
  • 出版日期:2015-08-08 发布日期:2015-06-29
  • 通讯作者: 庞达,Email:pangdasir@163.com E-mail:pangdasir@163.com
  • 基金资助:

    国家自然科学基金(81202075)

The progress of fibroblast growth factor receptor 3 in breast cancer

 WU  Hao, JIANG  Yong-Dong, PANG  Da   

  1. Department of Breast Surgery, Third Affiliated Hospital of Harbin Medical University, Harbin 150081, China
  • Online:2015-08-08 Published:2015-06-29
  • Contact: Pang Da E-mail:pangdasir@163.com

摘要: 成纤维细胞生长因子受体3(FGFR3)在调节细胞的增殖、分化及血管形成中发挥重要作用。近年来,研究发现FGFR3在乳腺癌发生发展和内分泌治疗耐药性乳腺癌中发挥一定的作用,并且与乳腺癌患者的预后密切相关。

关键词: 乳腺肿瘤, 受体, 成纤维细胞生长因子, 3型

Abstract: Fibroblast growth factor receptor 3(FGFR3) plays important roles in cell proliferation, differentiation, and angiogenesis. Recent studies have demonstrated that FGFR3 is associated with progression of breast cancer and has effects in endocrine therapy resistance breast cancer. It has also been showed that FGFR3 is correlated with breast cancer prognosis.

Key words: Breast neoplasms, Receptor, fibroblast growth factor, type 3