Tbx3基因在肿瘤进展中的机制研究

doi:10.3760/cma.j.issn.1673-422X.2015.01.009

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (1): 37-39.doi: 10.3760/cma.j.issn.1673-422X.2015.01.009

Tbx3基因在肿瘤进展中的机制研究

单泽志, 严雪冰, 田源, 金志明

200233上海交通大学附属第六人民医院普外科

收稿日期:2014-06-03 修回日期:2014-07-11 出版日期:2015-01-08 发布日期:2015-01-07
通讯作者: 金志明 E-mail:jzmgyp@aliyun.com

Mechanism research of Tbx3 gene in tumor progression

Shan Zezhi, Yan Xuebing, Tian Yuan, Jin Zhiming

Department of General Surgery, Sixth People’s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China

Received:2014-06-03 Revised:2014-07-11 Online:2015-01-08 Published:2015-01-07
Contact: Jin Zhiming E-mail:jzmgyp@aliyun.com

摘要/Abstract

摘要： Tbx3(T-box3)基因作为T-box家族的成员之一，广泛存在于人体的多种组织和器官中，参与了胚胎时期乳腺、四肢、心脏、眼、肺、胰腺的发育调控，并且在维持胚胎干细胞的发育中发挥了重要作用。最新研究表明，Tbx3可以作为转录因子通过上皮间质转化、肿瘤干细胞和甲基化等多种途径参与肿瘤的发生和发展。更好地了解Tbx3将为肿瘤的基因诊断和靶向治疗提供新的思路。

关键词: 肿瘤干细胞, 甲基化, Tbx3, 上皮间质转化

Abstract: As a member of Tbox family, Tbx3 (Tbox3) is widely expressed in multiple organs and involves in the development of breast, limb, heart, eye, lung and pancreas during embryonic development stage. Moreover, Tbx3 plays an important role in maintaining the embryonic stem cells. Recent studies show that Tbx3 can work as a transcription factor to participate in the initiation and progression of tumor by epithelialmesenchymal transition, induction tumor stemness and methylation. A better understanding of Tbx3 will provide new insights into genetic diagnosis and targeted treatment of tumor.

Key words: Neoplastic stem cells, Methylation, Tbx3, Epithelial-mesenchymal transition

单泽志, 严雪冰, 田源, 金志明. Tbx3基因在肿瘤进展中的机制研究[J]. 国际肿瘤学杂志, 2015, 42(1): 37-39.

Shan Zezhi, Yan Xuebing, Tian Yuan, Jin Zhiming. Mechanism research of Tbx3 gene in tumor progression[J]. Journal of International Oncology, 2015, 42(1): 37-39.

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Tbx3基因在肿瘤进展中的机制研究

Mechanism research of Tbx3 gene in tumor progression

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