国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (6): 362-365.doi: 10.3760/cma.j.issn.1673-422X.2019.06.010

• 综述 • 上一篇    下一篇

三阴性乳腺癌干细胞研究进展

亢野1李建一2杨向红1   

  1. 1中国医科大学附属盛京医院病理科，沈阳110000； 2中国医科大学附属盛京医院第一乳腺外科，沈阳110000
  • 出版日期:2019-06-08 发布日期:2019-07-11
  • 通讯作者: 杨向红，Email: xhyang4933@vip.sina.com E-mail:xhyang4933@vip.sina.com
  • 基金资助:
    国家自然科学基金（81528010）

Research progress of cancer stem cells in triplenegative breast cancer

Kang Ye1, Li Jianyi2, Yang Xianghong1   

  1. 1Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110000, China; 2First Department of Breast Surgery, Shengjing Hospital of China Medical University, Shenyang 110000, China
  • Online:2019-06-08 Published:2019-07-11
  • Contact: Yang Xianghong, Email: xhyang4933@vip.sina.com E-mail:xhyang4933@vip.sina.com
  • Supported by:
    National Natural Science Foundation of China (81528010)

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摘要： 三阴性乳腺癌（TNBC）富含肿瘤干细胞（CSC），并具有独特的维持其CSC表型的分子机制和肿瘤微环境。CSC可促进TNBC的化疗耐药与复发。阻断关键分子或改变肿瘤微环境能够削减CSC，进而抑制TNBC的肿瘤生长，并逆转化疗耐药。

关键词: 乳腺肿瘤, 肿瘤干细胞, 治疗, 抗药性, 三阴性乳腺癌

Abstract: There are abundant cancer stem cells (CSCs) in triplenegative breast cancer (TNBC). CSCs can maintain their phenotype by unique molecular mechanism and tumor microenvironment, and can promote the chemotherapy resistance and recurrence of TNBC. Blocking these key molecules or altering tumor microenvironment can reduce CSCs, and then inhibited cancer growth and reverse chemotherapy resistance of TNBC.

Key words: Breast neoplasms, Neoplastic stem cells, Therapy, Drug resistance, Triple negative breast neoplasms