国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (6): 358-361.doi: 10.3760/cma.j.issn.1673-422X.2019.06.009

• 综述 • 上一篇    下一篇

肿瘤相关成纤维细胞的机制研究及其在乳腺癌中的临床应用

叶佳慧,张伟杰   

  1. 南京大学 南京大学医学院附属鼓楼医院普外科210008
  • 出版日期:2019-06-08 发布日期:2019-07-11
  • 通讯作者: 张伟杰，Email: zhangweijie1616@163.com E-mail:zhangweijie1616@163.com
  • 基金资助:

    国家自然科学基金（81672380）

Mechanism study of cancer-associated fibroblasts and clinical application in breast cancer

Ye Jiahui, Zhang Weijie   

  1. Department of General Surgery, Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School, Nanjing University, Nanjing 210008, China
  • Online:2019-06-08 Published:2019-07-11
  • Contact: Zhang Weijie, Email: zhangweijie1616@163.com E-mail:zhangweijie1616@163.com
  • Supported by:

    National Natural Science Foundation of China (81672380)

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摘要： 乳腺癌的发生、发展是多因素相互作用的复杂过程，肿瘤相关成纤维细胞（CAF）分泌多种因子可导致乳腺癌的发生，诱导肿瘤血管生成，促进肿瘤的转移，诱导肿瘤耐药；同时，亦可通过CAF的表达判断患者的临床预后。CAF有望成为肿瘤治疗的新靶点。

关键词: 癌相关成纤维细胞, 乳腺肿瘤, 肿瘤微环境, 生物标记, 预后

Abstract: The occurrence and development of breast cancer is a complex process which referring to multifactor interaction. During this process, cancerassociated fibroblasts (CAFs) secrect various growth factors and cytokines to promote the tumor progression, angiogenesis, metastasis, drug resistance. Meanwhile, it can also judge the prognosis of patients through the expression of CAFs. CAFs may offer a new therapeutic strategy against breast cancer.

Key words: Cancerassociated fibroblasts, Breast neoplasms, Tumor microenvironment, Biomarkers, Prognosis