m 6A甲基化与乳腺癌

doi:10.3760/cma.j.cn371439-20200703-00114

摘要/Abstract

摘要：

m⁶A甲基化可以调节机体RNA的代谢,参与乳腺癌的发病过程。m⁶A甲基转移酶、m⁶A去甲基化酶、m⁶A结合蛋白共同调节m⁶A甲基化修饰的动态可逆过程。近年来研究显示甲基转移酶样蛋白(METTL)3、MELLT14、KIAA1429、去甲基化酶脂肪和肥胖相关蛋白、YTH结构域家族蛋白1~3等相关因子在乳腺癌中异常表达,可能通过调节m⁶A甲基化和去甲基化过程影响乳腺癌的发生与发展,对其进行深入研究将为乳腺癌的临床诊治提供一个新的思路和靶点。

关键词: 甲基化, 乳腺肿瘤, 调控蛋白

Abstract:

m⁶A methylation can regulate RNA metabolism and participates in the pathogenesis of breast cancer. m⁶A methyltransferase, demethylase and methylated binding protein regulate the dynamic and reversible process of m⁶A methylation modification together. In recent years, studies have shown that methyltransferase-like (METTL)3, MELLT14, KIAA1429, fat-mass and obesity associated protein, YTH domain family member 1-3 and other related factors are abnormally expressed in breast cancer, which may affect the occurrence and development of breast cancer by regulating the methylation and demethylation process of m⁶A. Further studies will provide a new idea and target for clinical diagnosis and treatment of breast cancer.

Key words: Methylation, Breast neoplasms, Regulatory proteins

尹剑云, 王培伟, 顾建伟. m ⁶A甲基化与乳腺癌[J]. 国际肿瘤学杂志, 2020, 47(12): 752-755.

Yin Jianyun, Wang Peiwei, Gu Jianwei. m⁶A methylation and breast cancer[J]. Journal of International Oncology, 2020, 47(12): 752-755.

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m ⁶A甲基化与乳腺癌

m⁶A methylation and breast cancer

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