SIRT1基因在肿瘤中的作用机制

doi:10.3760/cma.j.issn.1673-422X.2015.01.010

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (1): 40-42.doi: 10.3760/cma.j.issn.1673-422X.2015.01.010

SIRT1基因在肿瘤中的作用机制

马威, 卢颖, 毛俊, 赵文月, 李连宏

116044大连医科大学病理学教研室辽宁省肿瘤干细胞重点实验室

收稿日期:2014-06-19 修回日期:2014-07-16 出版日期:2015-01-08 发布日期:2015-01-07
通讯作者: 李连宏 E-mail:lilianhong917@126.com
基金资助:
国家自然科学基金（81272430）

Functional mechanism of SIRT1 gene in tumor

Ma Wei, Lu Ying, Mao Jun, Zhao Wenyue, Li Lianhong

Department of Pathology, Dalian Medical University, Key Laboratory of Tumor Stem Cell Research of Liaoning Province, Dalian 116044, China

Received:2014-06-19 Revised:2014-07-16 Online:2015-01-08 Published:2015-01-07
Contact: Li Lianhong E-mail:lilianhong917@126.com

摘要/Abstract

摘要： Ⅲ类去乙酰化酶Sirtuin 1(SIRT1)是一种依赖NAD+的组蛋白去乙酰化酶。研究发现SIRT1在肿瘤中的作用具有双面性，它可通过抑制炎症、肿瘤血管形成及与肿瘤相关基因相互作用等机制抑制肿瘤的发生发展；也可通过调控肿瘤相关基因、上皮间质转化、促进肿瘤细胞增殖和肿瘤放化疗耐受以及维持肿瘤干细胞的存活等机制促进肿瘤的增殖、侵袭和转移。

关键词: 肿瘤, 基因, 肿瘤抑制, 致癌物, SIRT1

Abstract: Sirtuin 1 （SIRT1）, the Ⅲ class deacetylation enzyme, is a kind of NAD+ dependent histone deacetylation enzyme. The role of SIRT1 in tumor has the duality. It can inhibit inflammation, tumor angiogenesis and interact with tumor related gene to inhibit tumor development. However, it can also regulate tumor related genes, and epithelialmesenchymal transition, promote tumor cell proliferation and tolerance of radiotherapy and chemotherapy, and maintain the stemness of cancer stem cells to promote tumor proliferation, invasion and metastasis.

Key words: Neoplasms, Genes, tumor suppressor, Carcinogens, SIRT1

马威, 卢颖, 毛俊, 赵文月, 李连宏. SIRT1基因在肿瘤中的作用机制[J]. 国际肿瘤学杂志, 2015, 42(1): 40-42.

Ma Wei, Lu Ying, Mao Jun, Zhao Wenyue, Li Lianhong. Functional mechanism of SIRT1 gene in tumor[J]. Journal of International Oncology, 2015, 42(1): 40-42.

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SIRT1基因在肿瘤中的作用机制

Functional mechanism of SIRT1 gene in tumor

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