国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (7): 511-514.doi: 10.3760/cma.j.issn.1673422X.2014.07.009

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细胞分裂周期蛋白25同源蛋白C与肿瘤放疗敏感性

尹亚超, 李多杰   

  1. 233000 蚌埠医学院第一附属医院肿瘤放疗科
  • 出版日期:2014-08-04 发布日期:2014-08-04
  • 通讯作者: 李多杰，Email: liduojie@163.com E-mail:liduojie@163.com

Research progress of cell division cycle 25 homolog C and tumor  radiosensitivity

 YIN  Ya-Chao, LI  Duo-Jie   

  1. Department of Radiotherapy, The First affiliated Hospital of Bengbu Medical College, Bengbu 233000, China
  • Online:2014-08-04 Published:2014-08-04
  • Contact: LI Duo-Jie E-mail:liduojie@163.com

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1171

被引次数

3

摘要： 细胞分裂周期蛋白25同源蛋白C(Cdc25C)在真核细胞的有丝分裂中起重要调节作用。真核细胞中的G2M进程主要由细胞周期蛋白依赖性激酶1(CDK1)细胞周期蛋白B(cyclinB)复合物调控。CDK1cyclinB复合物由Cdc25C激活促进细胞从G2期进入M期，Cdc25C活性是细胞周期进入M期的关键之一。提高Cdc25C活性可促进G2M期转变，去除电离辐射诱导的G2M期阻滞，使损伤的DNA在未得到修复的情况下进入细胞分裂期，可导致细胞的增殖性死亡，而提高放疗敏感性。

关键词: Cdc25磷酸酶类, 辐射耐受性, 肿瘤, 细胞周期

Abstract: As one of the Cdc25 phosphatase family members, Cdc25C plays an important role in regulating mitosis of eukaryotic cells.In eukaryotic cells, CDK1cell cycle protein B (CyclinB) compound mainly control the process of G2M. The activity of Cdc25C is the key in cell cycle into M phase. It activates CDK1cyclinB complexes to promote cells from G2 to M phase . Improving Cdc25C activity can promote the G2M phase transition, and remove the G2M phase retardation induced by ionizing radiation, preventing the damaged DNA from repaired into the phase of cell division, resulting in cell death caused by excessive cell proliferation, thus enhance radiosensitivity.

Key words: Cdc25 phosphatases, Radiation tolerance, Neoplasms, Cell cycle