国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (7): 507-511.

• 综述 • 上一篇    下一篇

肿瘤PET乏氧显像剂及放疗乏氧增敏的应用

罗政, 朱华, 林新峰, 肖绍文, 杨志   

  1. 100142 北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科 恶性肿瘤发病机制及转化研究教育部重点实验室（罗政、朱华、林新峰、杨志）,放射治疗科（肖绍文）
  • 出版日期:2014-08-04 发布日期:2014-08-04
  • 通讯作者: 杨志，Email: pekyz@163.com E-mail:pekyz@163.com
  • 基金资助:

    国家自然科学基金（81371592、81172083）

PET hypoxia imaging and progress of enhancing radiosensitivity in hypoxic tumor

 LUO  Zheng, ZHU  Hua, LIN  Xin-Feng, XIAO  Shao-Wen, YANG  Zhi   

  1. *Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research, Beijing 100142, China
  • Online:2014-08-04 Published:2014-08-04
  • Contact: Yang Zhi E-mail:pekyz@163.com

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摘要： 肿瘤乏氧是影响肿瘤治疗疗效和预后的重要因素。随着正电子发射断层显像术（PET）在临床的广泛应用，PET乏氧显像剂的研发和应用成为目前乏氧显像领域的重要趋势。利用PET乏氧显像技术可以无创地探测肿瘤乏氧区域，这对优化肿瘤治疗决策特别是放疗乏氧增敏以及改善肿瘤预后具有重要意义。

关键词: 肿瘤, 放射性核素显像, 辐射增敏药, 正电子发射断层显像术

Abstract: Hypoxia is one of the most important factors influencing cancer therapy and clinical prognosis. With positron emission tomography (PET) widely adopted in clinical practice, the development and application of PET hypoxia imaging agents has been much popular in the field currently. PET hypoxia imaging can detect tumor hypoxia region noninvasively, which has important significance for optimizing cancer treatment decisions and improving the prognosis of cancer.

Key words: Neoplasms, Radionuclide imaging, Radiationsensitizing agents, Positronemission tomography