国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (6): 422-424.

• 综述 • 上一篇    下一篇

慢病毒载体及其在肿瘤基因治疗中的研究应用

 牛鑫, 邓志华   

  1. 030001 太原,山西医科大学第二医院消化内科
  • 出版日期:2014-06-08 发布日期:2014-05-08
  • 通讯作者: 邓志华,Email:ykdzh@hotmail.com E-mail:ykdzh@hotmail.com
  • 基金资助:

    山西省自然科学基金(20120110386)

Progress of lentiviral vector on neoplasms gene therapy research

 NIU  Xin, DENG  Zhi-Hua   

  1. Department of Gastroenterology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Online:2014-06-08 Published:2014-05-08
  • Contact: Deng Zhihua E-mail:ykdzh@hotmail.com

摘要: 慢病毒载体(LV)是逆转录病毒载体中的特殊成员,已成为当前基因治疗载体研究的热点。研究表明LV可使目的基因稳定表达于肿瘤细胞,在消化系统、血液系统及妇科肿瘤等基因治疗中作为转运工具发挥了重要作用,为肿瘤基因治疗提供了新途径。

关键词: 慢病毒属, 肿瘤, 基因疗法

Abstract: Lentiviral vectors (LV), a special member of retroviral vectors, has become hot in gene therapy research. Studies have shown that LV can make exogenous gene expressed stably in tumor cells. As a tool for transportation, LV plays a significant role in the gene therapy of digestive system, hematologic system and gynecological tumor, which provides a promising new way for neoplasms gene therapy.

Key words: Lentivirus, Neoplasms, Genetic therapy