国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (6): 412-415.

• 综述 • 上一篇    下一篇

SphKS1PS1PR信号通路在肿瘤发病机制中的作用

雷烨,许晓倩,王健民   

  1. 200433上海第二军医大学长海医院血液内科
  • 出版日期:2014-06-08 发布日期:2014-05-08
  • 通讯作者: 王健民，Email:jmwang@medmail.com.cn E-mail:jmwang@medmail.com.cn
  • 基金资助:

    国家自然科学基金（81100362）

Roles of SphKS1PS1PR signaling pathway in pathogenesis of tumors

LEI  Ye, XU  Xiao-Qian, WANG  Jian-Min   

  1. Department of Hematology, ChangHai Hospital, Second Military Medical University, Shanghai 200433, China
  • Online:2014-06-08 Published:2014-05-08
  • Contact: Wang Jianmin E-mail:jmwang@medmail.com.cn

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摘要： 1磷酸鞘氨醇（S1P）是一种具有生物活性的脂质信使，可由鞘氨醇激酶（SphK）催化产生，并作用于1磷酸鞘氨醇受体（S1PR）介导多种生物学行为。研究表明，SphK、S1P及S1PR的异常与白血病、乳腺癌、结肠癌、淋巴瘤等的发生发展密切相关，S1PR1与信号转导及转录激活子3（STAT3）的相互作用也参与了恶性肿瘤的发病，因而具有潜在的肿瘤治疗价值。

关键词: 肿瘤, STAT3转录因子, SphKS1PS1PR信号通路

Abstract: Sphingosine1phosphate (S1P) is a kind of bioactive messenger which is catalyzed by sphingosine kinases (SphK) and mediates various biological behaviors through binding to sphingosine1phosphate receptors(S1PR). Researches demonstrate that the aberration of SphK, S1P and S1PR is closely related to the occurrence and development of cancers, such as leukemia, breast cancer, colorectal cancer and lymphoma. The interaction between S1PR1 and signal transducer and activator of transcription 3 (STAT3) is shown to take part in the pathogenesis of malignant tumors as well. Therefore, they are considered to have the potential tumortreatment value.

Key words: Neoplasms, STAT3 transcription factor, SphKS1PS1PR signaling pathway