国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (6): 415-418.

• 综述 • 上一篇    下一篇

缺氧诱导因子-1α与上皮间质转化


曹纯,马晓洁,谭榜宪   

  1. 637000南充，川北医学院附属医院肿瘤科
  • 出版日期:2014-06-08 发布日期:2014-05-08

Relationship between factor1α and epithelial mesenchymal transformation

 CAO  Chun, MA  Xiao-Jie, TAN  Bang-Xian   

  1.  Department of Oncology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, China
  • Online:2014-06-08 Published:2014-05-08
  • Contact: Tan Bangxian E-mail:tbx_nsmc@126.com

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摘要： 缺氧诱导因子1α（HIF1α）是一种细胞缺氧应答调控因子，在多种恶性肿瘤中呈高表达。研究表明，HIF1α在上皮间质转化（EMT）过程中发挥重要作用，它可通过一系列信号通路及作用机制多方面、多层次地调控EMT的发生，参与肿瘤的侵袭和转移。探寻HIF1α调控EMT相关机制对开发新的、有效的肿瘤治疗方法有重要意义。

关键词: 缺氧诱导因子1, &alpha, 亚基, 信号传导, 肿瘤, 上皮间质转化

Abstract: Hypoxia inducible factor (HIF1α) is a hypoxia response regulator, which is highly expressed in malignant tumors. Researches have shown that   HIF1α plays an important role in epithelial mesenchymal transformation. It can regulate epithelial mesenchymal transition through a series of signal  pathways and mechanisms at many levels, to participate in the invasion and metastasis of tumors. To explore the mechanism of HIF1α controlling epithelial mesenchymal transformation has important significance for the development of new, effective tumor treatment methods.

Key words: Hypoxiainducible factor 1, alpha subunit, Signal transduction, Neoplasms, Epithelialmesenchymal transformation