国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 711-714.

• 论著 • 上一篇    下一篇

乳腺癌中CXCR4的表达及其与Hedgehog信号通路的相关性

徐双斐, 王杰, 庄志刚   

  1. 200040上海，同济大学附属第一妇婴保健院乳腺外科（徐双斐、庄志刚）；上海交通大学附属国际和平妇幼保健院乳腺外科（王杰）
  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 王杰，E-mail: jiewang76@hotmail.com E-mail:jiewang76@hotmail.com
  • 基金资助:

    国家自然科学基金（81001172）；上海市卫生局科研课题（20124164）

Expression of CXCR4 in breast cancer and the relationship between CXCR4 and Hedgehog signaling pathway

XU  Shuang-Fei, WANG  Jie, ZHUANG  Zhi-Gang   

  1. Department of Breast Surgery, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 200040, China
  • Online:2013-09-08 Published:2013-09-16
  • Contact: WANG Jie，E-mail: jiewang76@hotmail.com E-mail:jiewang76@hotmail.com

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摘要： 目的 检测乳腺癌组织中CXCR4及Smoothened（Smo）、Patched（Ptch）的表达，对CXCR4表达的临床意义进行分析，并评价CXCR4与Smo、Ptch之间的相关性。方法 以免疫组织化学染色法检测124例乳腺癌组织中CXCR4、Smo、Ptch的表达情况，并对其结果进行分析。结果 乳腺癌组织中CXCR4阳性表达率为66.9%，CXCR4与乳腺癌淋巴结转移呈正相关（r=0.181，P=0.044）；Smo、Ptch阳性表达率分别为58.9%和64.5%，与CXCR4表达呈正相关（r=0.189，P=0.036；r=0.230，P=0.010）。结论 CXCR4的表达与乳腺癌淋巴结转移有关，与Smo、Ptch表达呈正相关，当其与Hedgehog信号通路同时表达时或许与乳腺癌的复发风险增高相关。

关键词: 乳腺肿瘤, 受体, 趋化因子, 受体, CXCR4, 信号传导

Abstract: Objective To detect the expressions of CXCR4, Smoothened (Smo） and Patched (Ptch) in breast cancer, to analyze the clinical significance of the expression of CXCR4, and to evaluate the relationships among the CXCR4, Smo and Ptch. Methods The expressions of CXCR4, Smo and Ptch from 121 cases of breast cancer specimens were detected by immunohistochemistry, and the results were analyzed. Results The positive expression rate of CXCR4 in breast cancer was 66.9%, which was positively associated with the lymph node metastasis (r=0.181, P=0.044). The positive expression rates of Smo and Ptch in breast cancer were respectively 58.9% and 64.5%. The expressions of Smo and Ptch were positively associated with the expression of CXCR4 in breast cancer (r=0.189, P=0.036; r=0.230, P=0.010). Conclusion The expression of CXCR4 in breast cancer are associated with the lymph node metastasis. Patients with breast cancer who express both CXCR4 and Hedgehog signaling pathway may have a higher risk of recurrence.

Key words: Breast neoplasms, Receptors, chemokine, Receptors, CXCR4, Signal transduction