国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 708-711.

• 论著 • 上一篇    下一篇

MMP-2和MMP-9在食管癌中表达的研究

武志, 潘晓玲, 仲洁   

  1. 251200山东省禹城市人民医院胸外科（武志），手术室（潘晓玲），眼科（仲洁）
  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 仲洁，E-mail: zh2613@sina.com E-mail:zh2613@sina.com

Expressions of MMP-2 and MMP-9 in esophageal cancer

WU  Zhi, PAN  Xiao-Ling, ZHONG  Jie   

  1. Department of Thoracic Surgery, Yucheng People′s Hospital of Shandong Province, Yucheng 251200, China
  • Online:2013-09-08 Published:2013-09-16
  • Contact: Corresponding author: ZHONG Jie, E-mail: zh2613@sina.com E-mail:zh2613@sina.com

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1269

被引次数

14

摘要： 目的  分析基质金属蛋白酶（MMP）-2和MMP-9在食管癌患者血清中的表达与食管癌临床病理因素之间的关系。方法  应用酶联免疫吸附法检测60例食管癌患者血清中MMP-2、MMP-9的含量与患者年龄、性别、组织学类型、临床分期及区域淋巴结转移等临床病理因素之间的关系。结果  对照组血清中MMP-2和MMP-9的浓度均值分别为61.31、87.67 ng/ml，而食管癌患者血清中MMP-2和MMP-9的浓度均值分别121.66、169.73 ng/ml，均高于正常者血清中含量，差异有统计学意义（t=3.015, P=0.007; t=2.037, P=0.04）。MMP-2的含量与有无淋巴结转移（t=2.150, P=0.04）及临床分期有关（t=2.186, P=0.03），MMP-9的含量与有无淋巴结转移（t=2.390, P=0.02）及临床分期有关（t=2.149, P=0.03）。MMP-2和MMP-9的含量均与食管癌患者的年龄、性别﹑组织学类型无关（均P>0.05）。结论  MMP-2和MMP-9可能与食管癌的侵袭转移有关。

关键词: 食管肿瘤, 基质金属蛋白酶2, 基质金属蛋白酶9

Abstract: Objective  To analyze the expression levels of matrix metallo proteinase-2 (MMP-2) and matrix metallo proteinase-9 (MMP-9) in serum of patients with esophageal cancer, and to analyze the interrelations among MMP-2, MMP-9 and clinicopathologic characteristics of esophageal cancer. Methods  The levels of serum MMP-2, MMP-9 from 60 patients with esophageal cancer were detected by enzyme linked immunosorbent assay. The interrelations among MMP-2, MMP-9 and clinicopathologic characteristics of esophageal cancer including age, gender, histological type, whether or not lymph nodes metastasis and TNM staging were analyzed.  Results  The levels of MMP-2 and MMP-9 in control group were 61.31 ng/ml and 87.67 ng/ml, the levels of MMP-2 and MMP-9 in patients with esophageal cancer were 121.66 ng/ml and 169.73 ng/ml. The levels of MMP-2 and MMP-9 were significantly higher in patients with esophageal cancer than that of general population (t=3.015, P=0.007; t=2.037, P=0.04). The level of MMP-2 was significantly associated with whether or not lymph node metastasis (t=2.150, P=0.04) and clinical staging (t=2.186, P=0.03). The level of MMP-9 was significantly associated with whether or not lymph node metastasis (t=2.390, P=0.02) and clinical staging (t=2.149, P=0.03).The levels of MMP-2 and MMP-9 have no reference to age, gender and histological type (all P>0.05).  Conclusion  MMP-2 and MMP-9 may correlate with tumor invasion and metastasis in patients with esophageal cancer.

Key words: Esophageal neoplasms, Matrix metalloproteinase 2, Matrix metalloproteinase 9