尼妥珠单抗治疗食管鳞状细胞癌的应用进展

doi:10.3760/cma.j.cn371439-20220506-00093

摘要/Abstract

摘要：

食管鳞状细胞癌（ESCC）是我国食管癌最主要的病理类型,近年来随着分子靶向药物的发展,靶向治疗开始成为ESCC治疗领域的研究热点。尼妥珠单抗是我国第一个以表皮生长因子受体（EGFR）为靶点的人源化单克隆抗体,已被批准用于早期或局部晚期鼻咽癌的治疗。多项Ⅱ~Ⅲ期临床试验对尼妥珠单抗在ESCC治疗中的应用进行了探索,证实其在治疗中晚期ESCC中具有显著的疗效与生存获益,同时具备良好的安全性。

关键词: 食管肿瘤, 尼妥珠单抗, 靶向治疗

Abstract:

Esophageal squamous cell carcinoma （ESCC） is the most predominant pathological type of esophageal cancer in China. In recent years, with the development of molecular targeted drugs, targeted therapy has become a hot research topic in the field of ESCC treatment. Nimotuzumab is the first humanized monoclonal antibody targeting epidermal growth factor receptor （EGFR） in China, which has been approved for the treatment of early or locally advanced nasopharyngeal carcinoma. Several phase Ⅱ-Ⅲ clinical trials have explored the use of nimotuzumab in the treatment of ESCC, confirming its significant efficacy and survival benefit in the treatment of advanced ESCC, as well as its favorable safety profile.

Key words: Esophageal neoplasm, Nimotuzumab, Targeted therapy

戴李宸, 胡莉钧, 于静萍. 尼妥珠单抗治疗食管鳞状细胞癌的应用进展[J]. 国际肿瘤学杂志, 2022, 49(8): 484-489.

Dai Lichen, Hu Lijun, Yu Jingping. Advances of nimotuzumab in the treatment of esophageal squamous cell carcinoma[J]. Journal of International Oncology, 2022, 49(8): 484-489.

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