国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (5): 362-365.

• 综述 • 上一篇    下一篇

CXCL4及其受体与结直肠肿瘤

晁红雷, 汪昱   

  1. 200233上海交通大学附属第六人民医院普外科

  • 出版日期:2013-05-08 发布日期:2013-05-15
  • 通讯作者: 汪昱 E-mail:wangyu11122@sina.com

CXCL4 and its receptor in colorectal cancer

CHAO  Hong-Lei, WANG  Yu   

  1. Department of General Surgery, Affiliated Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2013-05-08 Published:2013-05-15
  • Contact: WANG Yu E-mail:wangyu11122@sina.com

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摘要： CXC趋化因子配体4（CXCL4）是一类血小板衍生的趋化因子，属于CXC亚家族。CXCL4的受体CXC趋化因子受体3（CXCR3）为七次跨膜的G蛋白耦联受体,其辅助受体为糖胺聚糖。CXCL4及其受体参与调控体内许多生物学过程，如免疫调节、炎症反应、内皮细胞增殖迁移及血管新生等。近年来研究表明，CXCL4及其受体对结直肠肿瘤的细胞生长、血管生成、浸润和转移等过程有显著影响。这为探讨结直肠肿瘤的发生机制及靶向治疗提供了新视角。

关键词: 血小板因子4, 受体, 趋化因子, 受体, CXCR3, 结直肠肿瘤

Abstract: CXC chemokine ligand 4 (CXCL4) is a platelet-derived chemokine, and it belongs to CXC subfamily. Its receptor is CXC chemokine receptor 3 (CXCR3), which belongs to the seven transmebrane G-protein-coupled receptor family, and its coreceptor is glycosaminoglycan (GAG). CXCL4 and its receptors take part in the regulation of many biological processes, such as immune regulation, inflammatory response, endothelial cell proliferation and migration and angiogenesis. Recent studies show that CXCL4 and its receptor have significant influence on the cell growth, angiogenesis, invasion and metastasis of colorectal cancer,which offers a new perspective to explore the mechanism of colorectal cancer and its targeted therapy.

Key words: Platelet factor 4, Receptors, chemokine, Receptors, CXCR3, Colorectal neoplasms