国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (8): 654-658.

• 综述 • 上一篇    下一篇

端粒结合蛋白复合体的生物功能及其与肿瘤发生的关系

郭轶先,孙婉玲,夏长青   

  1. 100053 北京，首都医科大学宣武医院血液科
  • 出版日期:2012-09-22 发布日期:2012-09-24

Telosome: biological function and its relationship with tumor

 GUO  Yi-Xian, SUN  Wan-Ling, XIA  Chang-Qing   

  1. Department of Hematology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
  • Online:2012-09-22 Published:2012-09-24

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摘要： 近年来研究表明，在维持肿瘤细胞的复制和增殖过程中端粒结构的完整性及其功能比端粒的长度有着更重要的作用，其中一种由6种端粒结合蛋白组成的端粒结合蛋白复合体在调节端粒酶活性、维持端粒长度和保护染色体末端起到重要作用，并且直接参与细胞有丝分裂进程的复杂调控。深入研究端粒结合蛋白复合体在肿瘤发病中的作用机制，对于寻求诊断和治疗的新途径具有十分重要的意义。

关键词: 端粒, 端粒结合蛋白, 肿瘤

Abstract: Recent studies show that the structure integrality and function are more important than the length of telomere in maintaining tumor cells reproduction and proliferation. Mammalian telomeres bound by a specialized sixprotein(TRF1,TRF2,TIN2,RAP1,POT1 and TPP1)complex known as telosome or shelterin, has fundamental role in the regulation of telomere activity, maintaining the length and protecting telomere chromosome terminal. Telosome is involved in the complex regulation of cell mitosis process. The study of the role of telomere binding protein complex in tumorigenesis is very important for searching new methods of tumor diagnosis and treatment.

Key words: Telomere, Telomere-binding proteins, Neoplasms