国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 837-839.

• 综述 • 上一篇    下一篇

PARP抑制剂抗肿瘤治疗研究进展

马强, 郝吉庆   

  1. 230032 合肥，安徽医科大学第一附属医院肿瘤内科
  • 出版日期:2012-11-08 发布日期:2012-11-16
  • 通讯作者: 郝吉庆 E-mail:ayfy_hjq@163.com

Poly ADP-ribose polymerase inhibitors in cancer therapy

MA  Qiang, HAO  Ji-Qing   

  1. Department of Medical Oncology, First Hospital of Anhui Medical University, Hefei 230022,China
  • Online:2012-11-08 Published:2012-11-16

PDF

1947

摘要： 聚ADP核糖聚合酶(PARP)在DNA损伤修复、维持基因组稳定性方面起着重要作用。因此PARP抑制剂能够抑制肿瘤细胞DNA损伤修复、增强肿瘤细胞DNA对损伤因素的敏感性。近年来PARP抑制剂的研究受到了越来越多的关注。PARP抑制剂单药可以在具有某些基因突变的肿瘤中发挥合成致死作用，与化疗或放疗联合能够增加肿瘤细胞对化疗或放疗的敏感性。PARP抑制剂有望在肿瘤治疗领域中发挥重要作用。

关键词: 聚ADP核糖聚合酶类, 酶抑制剂, DNA损伤, DNA修复酶类, 肿瘤

Abstract: Poly ADP ribose polymerases (PARP) play an important role in DNA damage repair and genome stability. So, PARP inhibitors can inhibit the DNA damage repairing of tumor cells and enhance the sensitivity of the DNA of tumor cells to damage factors. In recent years, PARP inhibitors have been more and more concerned. PARP inhibitors can kill tumor cells with certain genetic mutations alone by synthetic lethal effect. In addition, PARP inhibitors in combination with chemotherapy or radiotherapy can increase the sensitivity of tumor cells to the chemotherapy or radiotherapy. PARP inhibitors are expected to play an important role in cancer therapy.

Key words: Poly(ADP-ribose) polymerases, Enzyme inhibitors, DNA damage, DNA repair enzymes, Neoplasms