国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 840-843.

• 综述 • 上一篇    下一篇

核酸适体在肿瘤诊疗中的应用

李烨, 曹红勇, 袁爱华, 苗毅   

  1. 210006 南京医科大学附属南京医院 南京市第一医院普外科(李烨、曹红勇、袁爱华);南京医科大学第一附属医院 江苏省人民医院普外科(苗毅)
  • 出版日期:2012-11-08 发布日期:2012-11-16
  • 通讯作者: 曹红勇,E-mail: caohongy6167@163.com E-mail:caohongy6167@163.com

Applications of nucleic acid aptamers in cancer diagnosis and treatment

LI  Ye, CAO  Hong-Yong, YUAN  Ai-Hua, MIAO  Yi   

  1. Department of General Surgery, The Nanjing First Hospital and The People’s Hospital of Jiangsu Province Affiliated to Nanjing Medical University, Nanjing 210006,China
  • Online:2012-11-08 Published:2012-11-16
  • Contact: Corresponding author: CAO Hong-yong , E-mail: caohongy6167@163.com E-mail:caohongy6167@163.com

摘要: 核酸适体分子量小、穿透力强、结合靶标的范围广泛、与靶标结合力强、无免疫原性、性质稳定、易于合成和修饰,不仅具有分子识别功能,还具有信号转导及调控功能,故可作为分子识别的工具和治疗药物的载体用于多种疾病的诊断和治疗。

关键词: 肿瘤, 分子诊断技术, 治疗, 核酸适体

Abstract: Due to their small molecular weight, strong penetrating power, wide target range, strong ability of binding targets, stable quality, little immunogenicity, easiness to be synthesized and modified, and functional roles in molecular recognition and signal transduction, nucleic acid aptamers are now used as tools for molecular recognition and drugs delivery for the diagnosis and treatment of many diseases.

Key words: Neoplasms, Molecular diagnostic techniques, Therapy, Nucleic acid aptamer