国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 834-837.

• 综述 • 上一篇    下一篇

肿瘤细胞固有Toll样受体9信号通路的研究进展

费广茹, 任涛   

  1. 200120上海，同济大学附属东方医院呼吸科
  • 出版日期:2012-11-08 发布日期:2012-11-16
  • 基金资助:

    上海市青年科技启明星计划（跟踪）（10QH1402000）；上海市浦东新区卫生系统学科带头人计划（PWRd2010-01）；上海市科委基础研究重点项目（11JC1410900）

Research progress of TLR9 inherent signaling pathways in the tumor cells

FEI  Guang-Ru, REN  Tao   

  1. Department of Respiratory Disease, Dongfang Hospital, Tongji University, Shanghai 200120, China
  • Online:2012-11-08 Published:2012-11-16

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2116

被引次数

1

摘要： Toll样受体 (TLR)9与其配体非甲基化胞嘧啶-鸟嘌呤二核苷酸序列的DNA（CpG DNA）特异结合后启动下游信号级联，TLR9信号活化受颗粒体蛋白、可溶性核酸感应蛋白（HMGB1）和可溶性TLR9调控。TLR9不再局限表达于免疫细胞，还在多系统肿瘤细胞中表达，并参与维系与促进肿瘤细胞的恶性生物学行为。肿瘤细胞固有TLR9信号通路功能的阐明将为肿瘤控制提供新思路。

关键词: 肿瘤, 寡核苷酸类, Toll样受体9

Abstract: Specific activation of toll-Like Receptor 9 (TLR9) by ligand CpG DNA/ODN can initiate downstream signaling. The activation of TLR9 signaling is regulated by Granulin,  high-mobility group box-1 (HMGB1) and soluble TLR9. Interestingly, TLR9 is no longer only presented in the immune cells, but also expressed in many kinds of tumor cells. TLR9 is involved inmaintaining and promoting the malignant biological behaviors of tumor cells. Elucidation of the function of TLR9 inherent signaling pathways in the tumor cells will provide a novel idea for oncotherapy.

Key words: Neoplasms, Oligonucleotides, Toll-Like receptor 9