国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 831-833.

• 综述 • 上一篇    下一篇

HLA-G蛋白在肿瘤组织及患者血清中的表达及其在肿瘤免疫逃逸中的作用

刘玮, 凌志强, 毛伟敏   

  1. 310022杭州, 浙江省肿瘤医院浙江肿瘤研究所 浙江省胸部肿瘤诊治技术研究重点实验室
  • 出版日期:2012-11-08 发布日期:2012-11-16
  • 通讯作者: 毛伟敏,E-mail: maowm1218@163.com E-mail:maowm1218@163.com
  • 基金资助:

    浙江省自然科学基金资助项目(Y2080749,Y2091110);人事部留学人员科技活动项目择优资助项目(2008004);浙江省科技计划项目(2009C33143)

Expression of HLA-G in serum and tissue of cancer patients and its function in tumor immune escape

LIU  Wei, LING  Zhi-Qiang, MAO  Wei-Min   

  1. Zhejiang Cancer Research Institute ,Zhejiang Key Laboratory of the Diagnosis & Treatment Technology on Thoracic Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
  • Online:2012-11-08 Published:2012-11-16
  • Contact: Corresponding author:MAO Wei-min, E-mail: maowm1218@163.com E-mail:maowm1218@163.com

摘要: 随着对HLA-G蛋白作用机制的深入了解,越来越多的研究发现HLA-G与肿瘤免疫密切相关。大量研究显示在肿瘤患者的血浆、肿瘤组织中均可检测到HLA-G蛋白、mRNA的表达。

关键词: 肿瘤, 人类白细胞抗原G, 免疫逃逸, 肿瘤

Abstract: With depth understanding of the mechanism of HLA-G protein, more and more studies have found that HLA-G is closely related with tumor immunity. Numerous studies have shown that the expression of HLA-G protein and mRNA could be detected in patients with cancer.

Key words: Neoplasms, HLA-G antigens, Immune escape, tumor