国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 827-830.

• 综述 • 上一篇    下一篇

Wnt信号通路与肿瘤的研究进展

顾娟, 王学东, 潘兆麟, 黄利华   

  1. 214005 南京医科大学附属无锡市第五人民医院检验科
  • 出版日期:2012-11-08 发布日期:2012-11-16
  • 通讯作者: 王学东， Email: wxd729@126.com E-mail:wxd729@126.com

Wnt signaling pathway and tumor

GU  Juan, WANG  Xue-Dong, PAN  Zhao-Lin, HUANG  Li-Hua   

  1. Department of Clinical Laboratory, Fifth People’s Hospital of Wuxi, Affiliated Hospital of Nanjing Medical University, Wuxi 214005, China
  • Online:2012-11-08 Published:2012-11-16
  • Contact: Corresponding author: WANG Xue-dong, E-mail: wxd729@126.com E-mail:wxd729@126.com

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2519

被引次数

11

摘要： Wnt信号通路不仅与肿瘤侵袭转移的相关事件如癌细胞的迁移黏附、细胞外基质的降解及肿瘤的血管生成密切相关，而且在调节肿瘤干细胞的自我更新、增殖与分化中发挥重要作用，并且针对Wnt信号通路不同基因靶点的高特异性基因药物开发及其肿瘤靶向治疗方面也取得一定进展。

关键词: 肿瘤, 肿瘤干细胞, Wnt信号通路

Abstract: Wnt signaling pathway is not only closely related to tumor invasion and metastasis, such as cancer cells migration and adhesion, extracellular matrix degradation, and angiogenesis, but also plays an important role in self-renewal, proliferation and differentiation of tumor stem cells. Progress has been made in high specific genes drug development and targeted therapy against the Wnt signaling pathway.

Key words: Neoplasms, Neoplasm stem cells, Wnt signaling pathway