关键词: 肿瘤, 泛素蛋白连接酶类, Pirh2

Abstract: Pirh2 (p53-induced protein with a Ring-H2 domain), one of the ubiquitin-protein E3 ligases, can promote p53 degradation via ubiquitin-proteasome pathway, and repress the biological functions of p53. Researchers have found that the Pirh2 is overexpressed in many cancers, which suggests Pirh2 is probably correlated with tumorigenesis and cancer development, and it may become a promising cancer therapeutic target.

Key words: Neoplasms, Ubiquitin-protein ligases, Pirh2