国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 820-823.

• 综述 • 上一篇    下一篇

MMP-2和MMP-9在恶性肿瘤中的研究进展

张明明, 徐玉清   

  1. 150086 黑龙江省哈尔滨市哈尔滨医科大学第二附属医院肿瘤内科
  • 出版日期:2012-11-08 发布日期:2012-11-16
  • 通讯作者: 徐玉清，E-mail: xyuqing@yahoo.com E-mail:xyuqing@yahoo.com

MMP-2 and MMP-9 in malignant tumor

ZHANG  Ming-Ming, XU  Yu-Qing   

  1. Department of Medical Oncology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China
  • Online:2012-11-08 Published:2012-11-16
  • Contact: Corresponding author：XU Yu-qing, E-mail: xyuqing@yahoo.com E-mail:xyuqing@yahoo.com

PDF

2445

被引次数

19

摘要： 基质金属蛋白酶 (MMP)-2和MMP-9属于基质金属蛋白酶家族的明胶酶类，能够降解细胞外基质，在肿瘤细胞生长、分化、侵袭、转移、调节肿瘤血管生成及免疫监视中起到重要作用，因此与多种肿瘤的发生和发展密切相关。近几年，针对MMP-2和MMP-9的抑制剂与药物也受到广泛关注。

关键词: 基质金属蛋白酶2, 基质金属蛋白酶9, 肿瘤

Abstract: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are gelatinases of matrix metalloproteinase family, which play a crucial role in the cancer cell growth, differentiation, invasion, migration, the regulation of tumour angiogenesis and immune surveillance because of their ability to degrade extracellular matrix proteins.So they are significantly associated with development and progression of various tumors. In recent years, the inhibitors and drugs against MMP-2 and MMP-9 arouse wide concern.

Key words: Matrix metalloproteinase2, Matrix metalloproteinase9, Neoplasms