国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (10): 741-744.

• 综述 • 上一篇    下一篇

Livin基因在肿瘤中的研究

尚娜娜,徐玉清   

  1. 150086 哈尔滨医科大学附属第二医院肿瘤内科
  • 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 徐玉清，xyuqing@yahoo.com E-mail:xyuqing@yahoo.com

Research progress of Livin gene in tumors

 SHANG  Na-Na, XU  Yu-Qing   

  1. Department of Oncology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: XU Yu-qing, E-mail: xyuqing@yahoo.com E-mail:xyuqing@yahoo.com

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被引次数

2

摘要： Livin是凋亡抑制蛋白家族的新成员，在多种肿瘤中高表达，与肿瘤的发生、发展、治疗及预后密切相关。多种研究证明，RNA干扰Livin后能抑制肿瘤生长，促进肿瘤细胞凋亡，并能增强肿瘤细胞对放化疗的敏感性。Livin在caspases的作用下发生裂解，产生的缩短片段具有促进肿瘤细胞凋亡的作用，为肿瘤治疗提供了新的方向。

关键词: 基因, 细胞凋亡, 肿瘤

Abstract: Livin, a novel member of human inhibitor of apoptosis protein family, is highly expressed in various malignant tumors. It plays an important role in the initiation, development，treatment and prognosis of tumors. Many studies have proved that downregulation of Livin expression using RNA interference technique can reduce tumor growth, increase the apoptotic rate, and sensitize tumor cells to radiotherapy and chemotherapy. Fulllength Livin is cleaved by the effector caspases to produce a truncated form (tLivin) with apoptosispromotion activity. tLivin provides a new direction for the treatment of the malignant tumors.

Key words: Gene, Apoptosis, Neoplasms