国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (10): 735-737.

• 综述 • 上一篇    下一篇

Wnt信号通路抑制因子SOX17在肿瘤中的研究

崔素芬,王志志,张玲玲   

  1. 225012 扬州市第一人民医院妇产科
  • 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 张玲玲，E-mail: fckzhang@163.com E-mail:fckzhang@163.com

Wnt signaling pathway antagonist SOX17 in cancer

 CUI  Su-Fen, WANG  Zhi-Zhi, ZHANG  Ling-Ling   

  1. Department of Gynecology and Obstetrics, Yangzhou No.1 People′s Hospital, Yangzhou 225012, China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: ZHANG Ling-ling, E-mail: fckzhang@163.com E-mail:fckzhang@163.com

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被引次数

2

摘要： SOX17作为SOX转录因子超家族的一员，在进化过程中高度保守，对胚胎内胚层的形成具有重要作用。研究发现，SOX17基因启动子高甲基化可导致其表达沉默或减少，从而异常激活经典Wnt信号通路，在肿瘤的形成和进展中具有至关重要的作用。

关键词: 肿瘤, SOX17蛋白, Wnt信号通路

Abstract: SOX17, a member of the SOX family of transcription factors, is conserved in many species and plays an important role in the formation of embryo endoderm. A number of studies have found that SOX17 gene expression is silenced or decreased might be due to promoter hypermethylation, which plays a vital role in tumorigenesis and tumor progression, and may contribute to aberrant activation of canonical Wnt signaling pathway in several human malignant tumors. 

Key words: Neoplasms, SOX17 protein, Wnt signaling pathway