国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (10): 732-734.

• 综述 • 上一篇    下一篇

miR-205与肿瘤

侯新新,赵萌,张贵宇   

  1. 250012 济南，山东大学齐鲁医院妇产科
  • 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 张贵宇，E-mail:zgy5566@yahoo.com.cn E-mail:zgy5566@yahoo.com.cn
  • 基金资助:

    山东省科技攻关项目（2008GG10002058）

miR-205 and cancer

 HOU  Xin-Xin, ZHAO  Meng, ZHANG  Gui-Yu   

  1. Department of Gynecology and Obstetrics, Qilu Hospital, Shandong University, Jinan 250012, China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: ZHANG Gui-yu, E-mail: zgy5566@yahoo.com.cn E-mail:zgy5566@yahoo.com.cn

PDF

1882

被引次数

6

摘要： miR-205在多种肿瘤中存在差异性表达，与肿瘤的发生发展及转移等过程密切相关。miR-205可通过与特定靶基因结合参与调控肿瘤细胞的增殖、分化、原位侵袭及远处转移等生物学行为。对miR-205的深入研究，有望对肿瘤的诊断、靶向治疗及预后等发挥重要作用。

关键词: 微RNAs, 肿瘤, 生物学标记

Abstract: miR-205 is differentially expressed in tumor tissues and is closely related to tumorigenesis and tumor metastasis. miR-205 can regulate the biological behaviors of tumor cells such as cell proliferation, differentiation, in situ invasion and distant metastasis by posttranscriptional regulation through binding to targeted genes. Additionally, further research of miR-205 may be helpful for tumor diagnosis, targeted therapy and prognosis.

Key words: microRNAs, Neoplasms, Biological markers