国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (2): 122-124.doi: 10.3760/cma.j.issn.1673422X.2017.01.011

• 综述 • 上一篇    下一篇

大蒜内烯丙基硫在恶性肿瘤中的作用

陈雪艳,熊婷,刘晓旺,陈霄霄,李丽丁,田雯,谢伟全,涂剑   

  1. 421001衡阳，南华大学药理药物研究所
  • 出版日期:2017-02-08 发布日期:2017-01-04
  • 通讯作者: 涂剑，Email: tujian0734@aliyun.com E-mail:tujian0734@aliyun.com
  • 基金资助:

    国家自然科学基金（81541163）； 湖南省自然科学基金（2015JJ3101）； 湖南省教育厅创新平台开放基金（15K111）； “湖南省分子靶标新药研究协同创新中心”培育项目（2014405）； 南华大学分子靶标新药协同创新中心大学生创新项目（0223000200021）； 南华大学大学生创新性课题（2016NH049XJXZ）

The role of garlic allyl sulfide in malignant tumor

Chen Xueyan, Xiong Ting, Liu Xiaowang, Chen Xiaoxiao, Li Liding, Tian Wen, Xie Weiquan, Tu Jian   

  1. Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Tu Jian E-mail:tujian0734@aliyun.com
  • Supported by:

    National Natural Science Foundation of China (81541163); Natural Science Foundation of Hunan Province of China (2015JJ3101); the Open Fund Based on Innovation Platform of Hunan Provincial Education Department (15K111); Hunan Provincial Cooperative Innovation Center for Molecular Target New Drug Study (2014405); Innovation Program of College in Cooperative Innovation Center for Molecular Target New Drug of University of South China (0223000200021); College Students′ Innovative Project of University of South China (2016NH049XJXZ)

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摘要： 大量流行病学研究显示，大蒜可以降低多种恶性肿瘤的发生率和死亡率，包括结肠癌、前列腺癌和胃癌等。大蒜的抗癌主要有效成分为烯丙基硫，其抗癌机制可能涉及调节信号转导通路、调控细胞周期、诱导细胞凋亡和分化，抑制肿瘤致癌基因的表达等。

关键词: 大蒜, 肿瘤, 烯丙基硫, 二烯丙基二硫, 二烯丙基三硫

Abstract: A large number of epidemiological studies have showed that garlic could reduce the incidence and mortality rates of variety cancers such as colon cancer, prostate cancer, stomach cancer, and so on. The main effective anticancer component in garlic was allyl sulfide. Its anticancer mechanisms included regulating signal transduction pathways, blocking the cell cycle, inducing apoptosis and differentiation of the tumor and inhibiting the expressions of oncogenes and so on.

Key words: Garlic, Neoplasms, Allyl sulfide, Diallyl disulfide, Diallyl trisulfide