国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (11): 682-685.doi: 10.3760/cma.j.issn.1673-422X.2019.11.008

• 综述 • 上一篇    下一篇

5-羟色胺及其受体在肿瘤发生发展中的作用

李扬1，2李中信3贾漪涛2   

  1. 1华北理工大学研究生学院，唐山063210； 2河北省人民医院肿瘤三科，石家庄050051；
    3河北医科大学第四医院外二科，石家庄050000
  • 出版日期:2019-11-08 发布日期:2019-12-26
  • 通讯作者: 贾漪涛 E-mail:jiayitao99@163.com

Effects of 5-hydroxytryptamine and receptors in tumorigenesis

Li Yang1,2, Li Zhongxin3, Jia Yitao2   

  1. 1Graduate School, North China University of Technology, Tangshan 063210, China; 2Third Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, China; 3Second Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Online:2019-11-08 Published:2019-12-26
  • Contact: Jia Yitao E-mail:jiayitao99@163.com

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摘要： 5-羟色胺（5-HT）在肿瘤发生发展过程中的作用受到越来越多的关注。除肠嗜铬细胞合成5-HT外，一些肿瘤细胞、免疫细胞也能分泌5-HT，且这些细胞表面存在不同的5-HT受体，5-HT作用于不同的受体，发挥多种生物学效应。5-HT激动其相应受体如5-HT1D等，能够促进肿瘤的增殖、侵袭，还可诱导肿瘤组织的血管形成。生理状态下的5-HT能够作用于免疫细胞表面的不同受体，促进免疫细胞的增殖、分泌，而在某些病理状态下，5-HT又能诱导免疫细胞向免疫抑制方向分化，从而参与肿瘤的发生发展。

关键词: 血清素, 受体, 免疫, 肿瘤

Abstract: The role of 5-hydroxytryptamine (5-HT) has attracted more and more attention in the development of tumor. In addition to the synthesis of 5-HT by enterochromaffin cells, some tumor cells and immune cells can also secrete 5-HT, and there are different 5-HT receptors on the surface of these cells. 5-HT plays multiple biological effects through activating different receptors. 5-HT promotes the proliferation and invasion of tumor and induces the angiogenesis of tumor tissues through activating its corresponding receptors, such as 5-HT1D, and so on. Furthermore, various 5-HT receptors are expressed on the surface of immune cells. On the one hand, physiological doses of 5-HT promote the proliferation and secretion of immune cells. On the other hand, pathologic 5-HT has an effect on inducing the differentiation of immune cells in the direction of immunosuppression, thus participating in the occurrence and development of tumor.

Key words: Serotonin, Receptors, Immunity, Neoplasms