国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (5): 303-306.doi: 10.3760/cma.j.issn.1673-422X.2019.05.011

• 综述 • 上一篇    下一篇

甲状腺激素水平与肾细胞癌及肝细胞癌多靶点TKI治疗疗效预测及其分子机制

孙月琴，李爱民，罗越，宋争徽，庄雪芬，戴冠齐，刘新会   

  1. 南方医科大学中西医结合医院肝胆胰肿瘤科，广州510315
  • 收稿日期:2019-02-22 出版日期:2019-05-08 发布日期:2019-06-14
  • 通讯作者: 刘新会 E-mail:liuxinhui89@126.com
  • 基金资助:

    国家自然科学基金（81572797）；广东省自然科学基金（2016A030311015）；广州市科技计划（201604020009）

Efficacy prediction and molecular mechanism of thyroid hormone levels and multi-target TKI therapy for renal cell carcinoma and hepatocellular carcinoma

Sun Yueqin, Li Aimin, Luo Yue, Song Zhenghui, Zhuang Xuefen, Dai Guanqi, Liu Xinhui   

  1. Department of Hepatobiliary and Pancreatic Oncology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, China
  • Received:2019-02-22 Online:2019-05-08 Published:2019-06-14
  • Contact: Liu Xinhui E-mail:liuxinhui89@126.com
  • Supported by:

    National Natural Science Foundation of China (81572797); Natural Science Foundation of Guangdong Province of China (2016A030311015); Science and Technology Project of Guangzhou City of China (201604020009)

PDF

453

摘要： 甲状腺功能减退是临床多靶点酪氨酸激酶抑制剂（TKI）的常见不良反应，可能作为TKI药物的疗效预测指标。研究发现甲状腺功能减退与接受多靶点TKI治疗的肾细胞癌患者良好预后显著相关，这可能与血管内皮细胞生长因子受体通路阻滞、潜在脱靶作用和细胞增殖受抑制有关；而在接受多靶点TKI治疗的肝细胞癌患者中，甲状腺功能减退则是预后不良的指标，这与T3/TR通路调控肝癌生长侵袭相关。在接受多靶点TKI药物治疗的不同肿瘤患者中，甲状腺激素水平的疗效预测功能及机制并不相同，仍需进一步深入研究。

关键词: 甲状腺激素类, 肿瘤, 预后, 酪氨酸激酶抑制剂

Abstract: Hypothyroidism is a common adverse reaction in clinical multi-target tyrosine kinase inhibitor  (TKI) and may be used as a predictor of efficacy of TKI drugs. Studies show that hypothyroidism is significantly associated with good prognosis in patients with renal cell carcinoma treated with multi-target TKI, which may be related to inhibition of vascular endothelial growth factor receptor pathway, potential offtarget effects and inhibition of cell proliferation. Whereas in the patients with hepatocellular carcinoma who received multi-target TKI therapy, hypothyroidism is an indicator of poor prognosis, which is related to the T3/TR pathway regulating liver cancer growth and invasion. The predictive function and mechanism of thyroid hormone levels in different tumor patients receiving multi-target TKI drugs are different, and further research is still needed.

Key words: Thyroid hormones, Neoplasms, Prognosis, Tyrosine kinase inhibitors