国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (11): 808-810.doi: 10.3760/cma.j.issn.1673-422X.2014.11.003

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程序性凋亡分子1及其配体信号通道对调节性T淋巴细胞及肿瘤细胞的影响

  

  1. 哈尔滨医科大学附属第一医院结肠直肠外科
  • 出版日期:2014-12-03 发布日期:2015-01-20
  • 通讯作者: 朴大勋，Email：piaodaxun@sina.com
  • 基金资助:

    黑龙江省自然科学基金重点项目（ZD201317）

Impact of the signal path PD-1/PD-L1 on Treg cells and tumor cells

  1. Department of Colorectal Surgery, Affiliated First Hospital of Harbin Medical University, Harbin 150081, China
  • Online:2014-12-03 Published:2015-01-20
  • Contact: Piao Daxun, Email: piaodaxun@sina.com

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摘要： 程序性凋亡分子1（PD1）及其配体（PDL1）是抑制性共同刺激分子中的重要成员之一，在多种肿瘤细胞及其相关细胞表面高表达，而肿瘤浸润的T淋巴细胞中调节性T淋巴细胞（Treg）的比例也异常升高。PDL1与PD1结合和Treg帮助肿瘤逃避免疫清除减弱了免疫应答和诱导免疫耐受。最新研究发现，PDL1分子是诱导型Treg（iTreg）发育和功能维持的重要分子，PDL1信号可将初始CD4+CD25-T细胞转化成iTreg，发挥免疫抑制作用。对PD1信号通道的研究可为抑制肿瘤免疫逃逸临床应用中肿瘤的免疫治疗提供新的理论依据和更好的治疗方法。

关键词: 肿瘤, T淋巴细胞, 肿瘤逃逸, 程序性细胞死亡受体1

Abstract: Programmed death1 (PD1) and its ligand PDL1 are the major members of inhibitory costimulatory molecules and express high in a variety of tumor cells and their associated cells surface, while the proportion of regulatory T cells (Tregs) are abnormally elevated in tumor infiltrating T lymphocytes cells. PDL1 combined with PD1 and Treg help tumors evade immune clearance, weaken immune responses and induce immune tolerance. New researches find that PDL1 plays an important role in the development and function maintenance of inducible Treg (iTreg), and PDL1 signal can change initial CD4+ CD25- T cells into iTreg to play a role of immunosuppression. Research on PD1 signaling pathway can provide a new theoretical basis for the inhibition of tumor immune escape in clinical application of immunotherapy and better treatments.

Key words: Neoplasms, T-lymphocytes, Tumor escape, Programmed cell death 1 receptor