三阴性乳腺癌分子靶向治疗

doi:10.3760/cma.j.issn.1673-422X.2014.09.007

摘要/Abstract

摘要： 由于不能从传统的内分泌治疗及针对人表皮生长因子受体2(HER2)的靶向治疗中获益，除手术治疗外，目前化疗是三阴性乳腺癌(TNBC)主要的全身治疗手段。由于传统化疗疗效不理想，TNBC的靶向治疗正成为研究热点。已有大量临床试验发现靶向聚二磷酸腺苷核糖聚合酶1(PARP1)抑制剂、血管内皮生长因子(VEGF)抑制剂、表皮生长因子受体(EGFR）抑制剂等能使TNBC患者不同程度获益。

关键词: 乳腺肿瘤, 抗肿瘤药, 靶向治疗

Abstract: Treatment options are limited for triple negative breast cancer (TNBC) since endocrinotherapy and targeted therapy that aims directly at human epidermal growth factor receptor-2 (HER-2) are ineffective. As such, in addition to surgical treatment, the mainstay of treatment of TNBC is systemic cytotoxic chemotherapy. The targeted therapy of TNBC is becoming a research hotspot because of traditional chemotherapy curative effect is not good enough. A large number of clinical trials have found that patients with TNBC can get benefits from targeted molecular strategies including polyadenosine diphosphate glucose pyrophospheralase-ribose polymerase-1 (PARP-1) inhibitor and epidermal growth factor receptor (EGFR) inhibitor.

Key words: Breast neoplasms, Antineoplastic agents, Molecular targeted therapy

贡丽娅,陈红风. 三阴性乳腺癌分子靶向治疗[J]. 国际肿瘤学杂志, 2014, 41(8): 662-665.

Gong Liya, Chen Hongfeng. Molecular targeted therapy of triple-negative breast cancer[J]. Journal of International Oncology, 2014, 41(8): 662-665.

参考文献

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