重离子治疗肿瘤的临床研究进展

doi:10.3760/cma.j.cn371439-20200117-00112

摘要/Abstract

摘要：

重离子放疗,特别是碳离子放疗,由于其良好的放射物理学特性和生物学效应在肿瘤放疗中逐渐受到重视。近年来研究发现,重离子放疗在不同实体瘤中均能取得较好的疗效。在不远的将来,如果重离子放疗能克服现有的技术困难则有望成为下一代放疗的主流。

Abstract:

Heavy ion radiotherapy, especially carbon ion radiotherapy, has been paid more attention in cancer radiotherapy because of its good radiophysical properties and biological effects. Recent studies show that the heavy ion is effective in treating solid tumors. In the near future, heavy ion radiotherapy is promising to become the mainstream of the next generation of radiotherapy if it overcomes the existing technical difficulties.

Key words: Neoplasms, Heavy ion radiotherapy, Carbon ion

王姗, 李萍, 张芮, 韩江龙, 胡钦勇, 付振明. 重离子治疗肿瘤的临床研究进展[J]. 国际肿瘤学杂志, 2020, 47(12): 741-745.

Wang Shan, Li Ping, Zhang Rui, Han Jianglong, Hu Qinyong, Fu Zhenming. Progresses in clinical research of heavy ion therapy for cancer[J]. Journal of International Oncology, 2020, 47(12): 741-745.

参考文献 31

[1]	王岚, 戴小亚. 全球质子重离子医院现状与展望[J]. 中国医院建筑与装备, 2016,14(1):27-31. DOI: 10.3969/j.issn.1671-9174.2016.01.002.
[2]	Wilson RR. Radiological use of fast protons[J]. Radiology, 1946,47(5):487-491. DOI: 10.1148/47.5.487. doi: 10.1148/47.5.487 pmid: 20274616
[3]	Kamada T. Twenty years of carbon ion radiation therapy at the national institute of radiological sciences: accomplishments and prospects[J]. Int J Part Ther, 2016,2(3):459-463. DOI: 10.14338/IJPT-15-00030.1. doi: 10.14338/IJPT-15-00030.1 pmid: 31772956
[4]	Durante M, Orecchia R, Loeffler JS. Charged-particle therapy in cancer: clinical uses and future perspectives[J]. Nat Rev Clin Oncol, 2017,14(8):483-495. DOI: 10.1038/nrclinonc.2017.30. doi: 10.1038/nrclinonc.2017.30 pmid: 28290489
[5]	Mohamad O, Makishima H, Kamada T. Evolution of carbon ion radiotherapy at the national institute of radiological sciences in Japan[J]. Cancers (Basel), 2018,10(3):66. DOI: 10.3390/cancers10030066. doi: 10.3390/cancers10030066
[6]	Mohamad O, Sishc BJ, Saha J, et al. Carbon ion radiotherapy: a review of clinical experiences and preclinical research, with an emphasis on DNA damage/repair[J]. Cancers (Basel), 2017,9(6):66. DOI: 10.3390/cancers9060066. doi: 10.3390/cancers9060066
[7]	Tsujii H, Mizoe JE, Kamada T, et al. Overview of clinical expe-riences on carbon ion radiotherapy at NIRS[J]. Radiother Oncol, 2004,73 Suppl 2: S41-S49. DOI: 10.1016/s0167-8140(04)80012-4.
[8]	Nomiya T, Tsuji H, Kawamura H, et al. A multi-institutional analysis of prospective studies of carbon ion radiotherapy for prostate can-cer: a report from the Japan Carbon ion Radiation Oncology Study Group (J-CROS)[J]. Radiother Oncol, 2016,121(2):288-293. DOI: 10.1016/j.radonc.2016.10.009. doi: 10.1016/j.radonc.2016.10.009 pmid: 27836119
[9]	Kim JY, Byun SJ, Kim YS, et al. Disease courses in patients with residual tumor following concurrent chemoradiotherapy for locally advanced cervical cancer[J]. Gynecol Oncol, 2017,144(1):34-39. DOI: 10.1016/j.ygyno.2016.10.032. doi: 10.1016/j.ygyno.2016.10.032 pmid: 27789082
[10]	Okonogi N, Wakatsuki M, Kato S, et al. A phase 1/2 study of carbon ion radiation therapy with concurrent chemotherapy for locally advanced uterine cervical squamous cell carcinoma (protocol 1302)[J]. Int J Radiat Oncol Biol Phys, 2019,104(3):631-639. DOI: 10.1016/j.ijrobp.2019.02.042. doi: 10.1016/j.ijrobp.2019.02.042 pmid: 30825494
[11]	Okonogi N, Wakatsuki M, Kato S, et al. Clinical outcomes of carbon ion radiotherapy with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma in a phase 1/2 clinical trial (protocol 1001)[J]. Cancer Med, 2018,7(2):351-359. DOI: 10.1002/cam4.1305. doi: 10.1002/cam4.1305 pmid: 29341491
[12]	Mizoe JE. Review of carbon ion radiotherapy for skull base tumors (especially chordomas)[J]. Rep Pract Oncol Radiother, 2016,21(4):356-360. DOI: 10.1016/j.rpor.2015.01.008. pmid: 27330420
[13]	Takagi M, Demizu Y, Hashimoto N, et al. Treatment outcomes of particle radiotherapy using protons or carbon ions as a single-modality therapy for adenoid cystic carcinoma of the head and neck[J]. Radiother Oncol, 2014,113(3):364-370. DOI: 10.1016/j.radonc.2014.11.031. doi: 10.1016/j.radonc.2014.11.031
[14]	Morimoto K, Demizu Y, Hashimoto N, et al. Particle radiotherapy using protons or carbon ions for unresectable locally advanced head and neck cancers with skull base invasion[J]. Jpn J Clin Oncol, 2014,44(5):428-434. DOI: 10.1093/jjco/hyu010. doi: 10.1093/jjco/hyu010
[15]	Kamada T, Tsujii H, Blakely EA, et al. Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience[J]. Lancet Oncol, 2015,16(2):e93-e100. DOI: 10.1016/S1470-2045(14)70412-7.
[16]	Shinoto M, Yamada S, Okamoto M, et al. Carbon-ion radiotherapy for locally recurrent rectal cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) study 1404 rectum[J]. Radiother Oncol, 2019,132:236-240. DOI: 10.1016/j.radonc.2018.10.007.
[17]	Qi WX, Fu S, Zhang Q, et al. Charged particle therapy versus photon therapy for patients with hepatocellular carcinoma: a systematic review and meta-analysis[J]. Radiother Oncol, 2015,114(3):289-295. DOI: 10.1016/j.radonc.2014.11.033. pmid: 25497556
[18]	Sanuki N, Takeda A, Kunieda E. Role of stereotactic body radiation therapy for hepatocellular carcinoma[J]. World J Gastroenterol, 2014,20(12):3100-3111. DOI: 10.3748/wjg.v20.i12.3100. pmid: 24696597
[19]	Yasuda S, Kato H, Imada H, et al. Long-term results of high-dose 2-fraction carbon ion radiation therapy for hepatocellular carcinoma[J]. Adv Radiat Oncol, 2019,5(2):196-203. DOI: 10.1016/j.adro.2019.09.007.
[20]	Robin TP, Goodman KA. Radiation therapy in the management of pancreatic adenocarcinoma: review of current evidence and future opportunities[J]. Chin Clin Oncol, 2017,6(3):28. DOI: 10.21037/cco.2017.06.12.
[21]	Shinoto M, Yamada S, Terashima K, et al. Carbon ion radiation therapy with concurrent gemcitabine for patients with locally advanced pancreatic cancer[J]. Int J Radiat Oncol Biol Phys, 2016,95(1):498-504. DOI: 10.1016/j.ijrobp.2015.12.362. doi: 10.1016/j.ijrobp.2015.12.362 pmid: 26883565
[22]	Mohamad O, Yamada S, Durante M. Clinical indications for carbon ion radiotherapy[J]. Clin Oncol (R Coll Radiol), 2018,30(5):317-329. DOI: 10.1016/j.clon.2018.01.006.
[23]	Kawashiro S, Yamada S, Okamoto M, et al. Multi-institutional study of carbon-ion radiotherapy for locally advanced pancreatic cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) study 1403 pancreas[J]. Int J Radiat Oncol Biol Phys, 2018,101(5):1212-1221. DOI: 10.1016/j.ijrobp.2018.04.057. doi: 10.1016/j.ijrobp.2018.04.057 pmid: 29907490
[24]	Isozaki Y, Yasuda S, Akutsu Y, et al. Salvage carbon-ion radio-therapy for isolated lymph node recurrence following curative resection of esophageal cancer[J]. Anticancer Res, 2018,38(11):6453-6458. DOI: 10.21873/anticanres.13007.
[25]	Yamamoto N, Miyamoto T, Nakajima M, et al. A dose escalation clinical trial of single-fraction carbon ion radiotherapy for peripheral stage Ⅰ non-small cell lung cancer[J]. J Thorac Oncol, 2017,12(4):673-680. DOI: 10.1016/j.jtho.2016.12.012. pmid: 28007628
[26]	Karube M, Yamamoto N, Tsuji H, et al. Carbon-ion re-irradiation for recurrences after initial treatment of stage Ⅰ non-small cell lung cancer with carbon-ion radiotherapy[J]. Radiother Oncol, 2017,125(1):31-35. DOI: 10.1016/j.radonc.2017.07.022.
[27]	Shirai K, Kawashima M, Saitoh JI, et al. Clinical outcomes using carbon-ion radiotherapy and dose-volume histogram comparison between carbon-ion radiotherapy and photon therapy for T2b-4N0M0 non-small cell lung cancer-a pilot study[J]. PLoS One, 2017,12(4):e0175589. DOI: 10.1371/journal.pone.0175589. doi: 10.1371/journal.pone.0175589 pmid: 28399182
[28]	Coggins WS, Pham NK, Nguyen AV, et al. A systematic review of ion radiotherapy in maintaining local control regarding atypical and anaplastic meningiomas[J]. World Neurosurg, 2019,132:282-291. DOI: 10.1016/j.wneu.2019.08.149.
[29]	EI Shafie RA, Czech M, Kessel KA, et al. Clinical outcome after particle therapy for meningiomas of the skull base: toxicity and local control in patients treated with active rasterscanning[J]. Radiat Oncol, 2018,13(1):54. DOI: 10.1186/s13014-018-1002-5.
[30]	Malouff TD, Peterson JL, Mahajan A, et al. Carbon ion radio-therapy in the treatment of gliomas: a review[J]. J Neurooncol, 2019,145(2):191-199. DOI: 10.1007/s11060-019-03303-y. doi: 10.1007/s11060-019-03303-y
[31]	Demizu Y, Jin D, Sulaiman NS, et al. Particle therapy using protons or carbon ions for unresectable or incompletely resected bone and soft tissue sarcomas of the pelvis[J]. Int J Radiat Oncol Biol Phys, 2017,98(2):367-374. DOI: 10.1016/j.ijrobp.2017.02.030.