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15 August 2014, Volume 41 Issue 8 Previous Issue    Next Issue

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Roles of RegⅣ in neoplasms and clinical applications Wu Yichen, Ying Lisha, Ling Zhiqiang 2014, 41 (8):  561-564.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.001 Abstract ( 420 )   PDF (1021KB) ( 1342 )   Save As a member of regenerating isletderived family, regenerating isletderived type Ⅳ (RegⅣ) is involved in cell proliferation and differentiation.  RegⅣ is closely related to the occurrence and development of tumor, tumor cell proliferation and invasion and antiapoptosis, and it may be a potential molecular target of targeting therapy in cancer. References | Related Articles | Metrics

Progression of tumor dormancy models Zhu Menghan, Feng Weiwei 2014, 41 (8):  564-567.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.002 Abstract ( 438 )   PDF (887KB) ( 1459 )   Save Tumor dormancy is a state that tumor cells longterm exist in human body, without obvious growth. Dormant cell is one of the origins of tumor recurrence or metastasis. The exact mechanism of tumor dormancy is still unclear. Combined with cellular and molecular biological techniques, tumor cell transplantation and culture in vitro can establish experimental tumor dormancyrecurrence models. These in vivo and in vitro models can be used to investigate mechanisms of tumor dormancy and to explore novel treatments. References | Related Articles | Metrics

Research progress of cancer induced by asbestos Li Hongmei, Zou Jianfang, Zhao Jinbi 2014, 41 (8):  567-570.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.003 Abstract ( 684 )   PDF (889KB) ( 1898 )   Save Asbestos is widely used in all walks of life, but the hazard of asbestos to human is currently a major public health problem all over the world, especially carcinogenicity. Asbestos can cause lung cancer, mesothelioma, throat cancer, digestive system cancer, ovarian cancer and other diseases. In recent years, epidemiological data and experimental results have confirmed the carcinogenicity of asbestos from multiple perspectives. References | Related Articles | Metrics

Application of microdialysis in tumor Zhou Jingchao, Li Juan, Liu Chunsheng, Zhou Dinghua, Tong Weihang, Wang Dan 2014, 41 (8):  570-573.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.004 Abstract ( 490 )   PDF (889KB) ( 1445 )   Save Microdialysis is an automatic biological sampling technique that is directed into the target tissue. Microdialysis is used to monitor the changes of drug and related substances associated with pathological physiology of tumor in the target tissue at the molecular level. Microdialysis is applied to evaluate the pharmacokinetics of drugs in the target tissue of tumor, optimize the combination therapy, explore molecular targeted therapy and study the early diagnosis and prognosis of tumor. Microdialysis provides a new idea and method for the prevention and cure research of tumor. References | Related Articles | Metrics

Influence factors of vincristine′s adverse reaction Huang Cheng, Ma Xiaoli 2014, 41 (8):  574-576.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.005 Abstract ( 350 )   PDF (818KB) ( 1549 )   Save During the treatment of pediatric tumor, vincristine is one of the most widely used and most effective drugs. However, the adverse reactions have limited its clinical application. In recent years, studies have found that the metabolism of vincristine are different in different races and different individuals, and coadministration with certain drugs such as imidazoles antifungal drugs may enhance its adverse reaction. Researches on new drug delivery system provide a new idea for reducing the adverse reactions of vincristine and improving its bioavailability. References | Related Articles | Metrics

Conversion chemotherapy of cancer Zhang Baihong, Yue Hongyun 2014, 41 (8):  576-578.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.006 Abstract ( 799 )   PDF (820KB) ( 1375 )   Save In patients with initially diagnosed unresectable cancers, resection of cancer sometimes becomes possible by systemic chemotherapy, and this model of chemotherapy is defined as conversion chemotherapy. Conversion chemotherapy can improve objective response rate and resection rate, and it has shown an important value in metastatic colorectal cancer, advanced gastric cancer and unresectable hepatocellular carcinoma. Related Articles | Metrics

Calcium channels in glioma Liu Yang, Wamg Yanming 2014, 41 (8):  579-582.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.007 Abstract ( 430 )   PDF (887KB) ( 1925 )   Save Calcium channels express abnormally in glioma, and play a key role in the physiological functions of glioma such as tumorigenesis, proliferation, metastasis and angiogenesis. Researches show that low or high expressions of different types of calcium channels have influence on the development of glioma and cellcycle redistribution. Such calcium channels may represent new targets in treating glioma,which provide new ideas for controlling glioma. References | Related Articles | Metrics

Treatment strategy for medullary thyroid cancer Bi Yalan, Meng Yunxiao, Cui Quancai 2014, 41 (8):  582-585.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.008 Abstract ( 725 )   PDF (887KB) ( 1224 )   Save Medullary thyroid cancer is a kind of rare malignancy arising from unregulated replication of parafollicular C cells of the thyroid gland. Therapeutic approaches to patients with medullary thyroid cancer have their own features, which are different from those to patients with papillary thyroid cancer, the most common type of thyroid cancer. The targeted therapy using tyrosine kinase inhibitors has brought new hope for the management of aggressive medullary thyroid cancer in recent years. References | Related Articles | Metrics

Postoperation TSH suppression therapy in differentiated thyroid carcinoma Hou Xiuxiu, Ge Minghua 2014, 41 (8):  585-587.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.009 Abstract ( 484 )   PDF (890KB) ( 1383 )   Save Surgical operation is still the main means of thyroid carcinoma, especially the differentiated thyroid carcinoma. Postoperative endocrine therapy is considered as an important adjuvant therapy. Giving the corresponding endocrine therapy after the surgery, not only prevent the hypothyroidism, but also reduce the recurrence rate and mortality in postoperative patients with thyroid carcinoma. References | Related Articles | Metrics

Prevention and therapy of small cell lung cancer with brain metastasis Gao Chao, Yu Yonghua 2014, 41 (8):  588-592.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.010 Abstract ( 750 )   PDF (890KB) ( 1292 )   Save Small cell lung cancer with brain metastasis is the most common type in brain metastasis tumors with the poor prognosis. Researches show that prophylactic cranial irradiation is not only effective in the prevention and treatment of limited disease brain metastases of small cell lung cancer, but also effective for extensive disease. Moreover, certain medications such as mannitol, nimustine etc also play an important supporting role, but there are many other uncertain parts in terms of prevention and treatment remaining controversial and needing further research. References | Related Articles | Metrics

Advances of anaplastic lymphoma kinase in non-small cell lung cancer Fang Shu, Pan Zhifeng 2014, 41 (8):  592-594.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.011 Abstract ( 433 )   PDF (891KB) ( 1286 )   Save Targeted therapy is the most prospective part of the research related to the treatment of nonsmall cell lung cancer (NSCLC). After epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) gene is expected to become a new target in the treatment of NSCLC. Moreover, several related researches suggest that ALK inhibitor (crizotinib) is effective for treatment of ALKrearranged NSCLC. Therefore, it is important to review the detection method of ALK gene, clinicopathologic features and the research progress of ALK inhibitor for the individual treatment of NSCLC. References | Related Articles | Metrics

Concurrent chemoradiation for local advanced esophageal carcinoma Zhang Guangming, Mao Wenkui, Huang Debo, Zhang Xuewei 2014, 41 (8):  595-598.  doi: 10.3760/cma.j.issn.1673422X.2014.08.012 Abstract ( 425 )   PDF (889KB) ( 1278 )   Save Comprehensive therapy is widely received for esophageal carcinoma in our country and worldwide. The treatment approaches consist of sugery, radiotherapy and chemotherapy, and chemoradiation therapy is very important. Many randomized controlled studies and metaanalysis reveal that preoperative neoadjuvant  chemoradiotherapy and radical concurrent chemoradiation are the preferred modalities for local advanced esophageal carcinoma. References | Related Articles | Metrics

Chemotherapy and molecular targeted therapy of advanced gastric cancer Pei Bo, Cun Yingli 2014, 41 (8):  599-602.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.013 Abstract ( 585 )   PDF (889KB) ( 1299 )   Save Chemotherapy and molecular targeted therapy are the main treatments in unresectable gastric cancer. In recent years, due to the adjustment and optimization of chemotherapy regimens which are consist of fluorouracil, platinum and taxane, the survival time of gastric cancer patient has been prolonged and the quality of life has been improved. The molecular targeted therapy in gastric cancer arouses more and more concern, and there are many phrase Ⅲ clinical trials which are used to assess the efficacy of molecular targeted therapy. The advances of chemotherapy and molecular targeted therapy bring new hope to advanced gastric cancer patients. Related Articles | Metrics

Effects and mechanisms of bevacizumab-induced renal impairment He Yi, Xu Qunhong, Chen Xueqin, Pan Yuelong, Wang Ming 2014, 41 (8):  602-605.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.014 Abstract ( 1719 )   PDF (889KB) ( 1466 )   Save Bevacizumab has been widely used in tumor targeting therapy, while the most common adverse reaction is renal impairment, manifested as proteinuria. The main mechanisms may include interfering podocytesendothelial vascular endothelial growth factor(VEGF) axis signals, increasing glomerular pressure caused by secondary hypertension, subacute renal thrombotic microangiopathy caused by endothelial damage and so on. Thrombotic microangiopathy is the main renal pathological type, and other rare types include glomerular lesions, renal interstitial disease, and benign renal arteriolar nephrosclerosis. Therefore, urine protein excretion and renal function should be closely monitored during bevacizumab treatment period for timely treatment, dose reduction or even withdrawal if necessary to ensure renal function. References | Related Articles | Metrics

Imageguided radiotherapy for bladder cancer Yang Aijie, Liu Jie, Wang Mingchen, Ma Ruizhong, Hao Furong 2014, 41 (8):  605-608.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.015 Abstract ( 450 )   PDF (890KB) ( 1351 )   Save Bladder cancer is a common malignant tumor in urinary system. The life quality of patients reduces obviously after radical resection of bladder. Comprehensive treatment including radiotherapy and chemotherapy after bladder preservation surgery plays an important role for the prevention of postoperative recurrence, preservation the function of bladder, and improving the life quality of patients. Imageguided radiotherapy can reduce the setup error and inner boundary caused by the movement of organs, and can alleviate the side reaction of radiation, and it also can provide basis of expanding boundary of planning target volume for the bladder cancer patients. References | Related Articles | Metrics

Expression and significance of human tissue kallikrein in ovarian cancer Chu Fangbo, Chen Yingjian, Hu Chengjin 2014, 41 (8):  608-611.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.016 Abstract ( 541 )   PDF (889KB) ( 1240 )   Save The human tissue kallikrein (KLK) gene family consists of 15 highly conservative serine proteases, which is the largest uninterrupted cluster of protease genes in the human genome. Several members of the family are expected to be markers for tumor diagnosis and prognosis. Studies find that the expressions of KLK2-11 and KLK13-15 are abnormal, and the majority of KLKs have potential diagnostic and prognostic values. References | Related Articles | Metrics

Expression and therapy of Prame gene on hematologic malignancies Liu Zhaoyun 2014, 41 (8):  611-614.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.017 Abstract ( 562 )   PDF (889KB) ( 1297 )   Save As a member of the family of cancertestis antigen, preferentially expressed antigen of melanoma (Prame) can improve the proliferation of tumor via inhibiting the retinoic acid receptor signal path and impeding the transcription factor which is a wide range of physiological processes in development and differentiation of tumor cells. Prame expresses in solid tumors and hematological malignancies, which is widely used for tumor diagnosis, monitoring of tumor metastasis and immunotherapy. References | Related Articles | Metrics

c-MET gene amplification in advanced primary non-small cell lung cancer and associated lymph node metastases Li Yang, Yu Zhonghe 2014, 41 (8):  615-619.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.018 Abstract ( 408 )   PDF (957KB) ( 1404 )   Save Objective To examine the positive rate of cMET gene amplification in primary and lymph nodemetastatic non-small cell lung cancer (NSCLC), and to explore their relationships. MethodsFrom November 2011 to November 2013, 147 cases of primary NSCLC consisting of 71 cases of paired lymph nodemetastatic tumors and 47 cases of normal lung specimens as the control group were collected in General Hospital of Beijing Military Region. The cMET gene copy number was examined by RTPCR and the positive rate of cMET gene amplification among NSCLC population was figured out, thus the consistency of c-MET gene amplification in advanced primary NSCLC and associated lymph nodemetastases and the relationship between cMET gene amplification and clinical data were analyzed. ResultsThe positive rate of cMET gene amplification on primary tumor was 8.84% (13/147). For those 71 paired cases, the positive rate on primary tumor was 8.45% (6/71), with that of lymph nodemetastases 18.31% (13/71). Among the 71 cases, there were 8 cases whose metastases were positive but primary tumors negative and 1 case whose primary tumor was positive but metastases negative. It was of statistical significance between the two groups (McNemar test, χ2=4.274, P=0.039). The positive rate of primary tumors could be predicted by lymph node metastases (κ=0.464, P＜0.001). The sensitivity was 83.3% and the specificity was 87.7%. Positive rate of c-MET amplification was higher in male and smoking patients with lymph node metastases above N2. ConclusioncMET amplification test should be one of the routine genetic testing projects. The amplification on primary tumors is higher than that on lymph nodemetastases, implying that metastases test can pick out more patients with indication. Metastases test can predict the amplification on primary focus, and it is an alternative way to guide the treatment of c-MET target medicine. Moreover, the clinical characteristic can be served as an indicator of positive c-MET amplification. Related Articles | Metrics

Clinical observation of albumin bound paclitaxel plus bevacizumab as second line therapy in patients with advanced pancreatic cancer Huang Shaojiang 2014, 41 (8):  620-623.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.019 Abstract ( 1456 )   PDF (1032KB) ( 1591 )   Save ObjectiveTo investigate the efficacy, adverse reaction and survival condition of albuminbound paclitaxel combined with bevacizumab as secondline therapy in patients with advanced pancreatic cancer. MethodsTwentyseven cases of advanced pancreatic cancer were enrolled to receive albuminbound paclitaxel combined with bevacizumab regimen. The dose of the drugs was as follows: albuminbound paclitaxel 130 mg/m2, d1, bevacizumab 7.5 mg/m2, d1. Twentyone days were a cycle for each regimen, and the least chemotherapy cycle was 2. The adverse reactions were evaluated for each cycle and the objective response was evaluated for 2 cycles. ResultsThe 27 patients could be evaluated. None was in complete remission, 2 cases were in partial remission, 14 cases were in stabilization, 11 cases were in progress. The response rate (RR) was 7.41%, and the disease control rate (DCR) was 59.26%. The median progress free survival (PFS) was 4 months (95％CI: 3.0044.996 months), and the median overall survival (OS) was 8 months (95％CI: 5.90010.100 months). The main adverse reactions included myelosuppression, gastrointestinal reaction, fatigue, lipsotrichia, erythra, peripheral neurotoxicity, etc, most of which were 12 grade. The adverse effect was well tolerated, and there was no treatmentrelated death. ConclusionThe albuminbound paclitaxel combined with bevacizumab as secondline therapy in patients with advanced pancreatic cancer shows slow progress and low adverse effect and needs further study. References | Related Articles | Metrics

Expression of Y-box-binding protein-1 and epithelialmesenchymal transition markers in colorectal cancer Yan Xuebing, Yan Leilei, Liu Sihong, Shan Zezhi, Jin Zhiming 2014, 41 (8):  624-628.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.020 Abstract ( 440 )   PDF (1751KB) ( 1195 )   Save ObjectiveTo detect the expressions of Yboxbinding protein1 (YB1) and epithelialmesenchymal transition (EMT) markers (Ecadherin and Ncadherin) in colorectal cancer (CRC), to analyze the relationship between the expression of YB1 and clinicopathological parameters, to evaluate the correlations among YB1, Ecadherin and Ncadherin. MethodsThe expressions of YB1, Ecadherin and Ncadherin in 120 primary CRC tumors and corresponding normal tissues were detected by western blot and immunohistochemistry and the results were analyzed. ResultsThe expressions of YB1, Ecadherin and Ncadherin in tumors were significantly different from those in corresponding normal tissues (χ2=47.373, P＜0.05; χ2=83.145, P＜0.05;χ2=41.832, P＜0.05). The expression of YB1 in tumors was associated significantly with tumor differentiation, tumor invasion, lymph node metastasis and distance metastasis (χ2=8.077, P=0.008; χ2=8.178, P=0.006; χ2=15.152, P＜0.001; χ2=7.368, P=0.011). It was negatively correlated with Ecadherin expression (r=-0.238, P=0.009), but positively correlated with Ncadherin expression (r=0.361, P＜0.001). ConclusionYB1 may promote the occurrence and development of CRC by participating in EMT program. References | Related Articles | Metrics

Effects of DCC gene on biological behaviors of colorectal carcinoma cell line SW1116 Jiang Hongwei, Wang Ju, Li Haijun, Peng Jikui, Gao Xiaoping, Chen Feng 2014, 41 (8):  628-632.  doi: 10.3760/cma.j.issn.1673-422X.2014.08.021 Abstract ( 396 )   PDF (1194KB) ( 1322 )   Save ObjectiveTo investigate the effects of exogenous wild DCC gene stably transfection on growth of colorectal carcinoma cell line SW1116 in vitro. MethodsDCC gene domain was amplified from human normal colon tissue by reverse transcriptpolymerase chain reaction (RTPCR). At first, a recombinant expression plasmid pcDNA3.1(+)DCC was constructed. Human colorectal carcinoma cell line SW1116 without DCC gene was transfected with pcDNA3.1DCC. Cell viability was tested by methyl thiazolyl tetrazolium (MTT) assay. Immunofluorescence staining was used to determine the effects of pcDNA3.1DCC and expression of carcinoembryonic antigen (CEA) in human colorectal carcinoma cell line SW1116 which was transfected with pcDNA3.1DCC. ResultsThe population of cells transfected with pcDNA3.1(+)DCC plasmid was lower than those with pcDNA3.1(+)DCC plasmid and normal cells (t=3.645, P＜0.05; t=3.132, P＜0.05) at 3～6 days after transfection, and the proliferation rate of cells transfected with pcDNA3.1(+)DCC plasmid was lower than those with pcDNA3.1(+) plasmid and normal cells (t=2.134, P＜0.05; t=2.736, P＜0.05). Cell line SW1116 transfected with pcDNA3.1(+)DCC plasmid total viability was lower than normal cells (t=3.053 ,P＜0.05) at 2～6 days after transfection. Cell line SW1116 transfected with pcDNA3.1(+)DCC plasmid total viability was lower than those with pcDNA3.1(+) plasmid (t=2.816, P＜0.05) at 2, 4, 5, 6 days after transfection. The population of flavogreen colour cells transfected with pcDNA3.1(+)DCC plasmid and the fluorescent intensity of these cells were lower than those with pcDNA3.1(+) plasmid and normal control cells. ConclusionTransfected DCC gene can suppress the cell proliferation and make CEA expression of cell line SW1116 down regulation to weaken its infiltration and metastasis abilities. References | Related Articles | Metrics