Abstract: During the treatment of pediatric tumor, vincristine is one of the most widely used and most effective drugs. However, the adverse reactions have limited its clinical application. In recent years, studies have found that the metabolism of vincristine are different in different races and different individuals, and coadministration with certain drugs such as imidazoles antifungal drugs may enhance its adverse reaction. Researches on new drug delivery system provide a new idea for reducing the adverse reactions of vincristine and improving its bioavailability.

Key words: Vincristine, Medication systems, Adverse reaction, Influence factors